Talmetacin

Base Information

• Chemical Name: Talmetacin
• CAS No.: 67489-39-8
• Molecular Formula: C27H20ClNO6
• Molecular Weight: 489.9038
• Mol file: 67489-39-8.mol

Synonyms:1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetic acid 1,3-dihydro-3-oxoisobenzofuran-1-yl ester;

Chemical Property of Talmetacin

Chemical Property:

• Vapor Pressure: 1.15E-15mmHg at 25°C
• Boiling Point: 627.6°Cat760mmHg
• Flash Point: 333.4°C
• PSA: 83.83000
• Density: 1.38g/cm³
• LogP: 5.25510

Purity/Quality:

97% ^*data from raw suppliers

TALMETACIN 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Analgesic; anti-inflammatory; antipyretic. Talmetacin is an analgesic and an anti-inflammatory drug.

Technology Process of Talmetacin

There total 2 articles about Talmetacin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-Bromophthalide (6940-49-4) + [1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid (53-86-1) → Talmetacin (67489-39-8)

Guidance literature:

With sodium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 24h; Inert atmosphere;

DOI:10.1016/j.dmpk.2021.100391

Reference yield:

→ Talmetacin (67489-39-8)

Guidance literature:

Aus Bromphthalid u. d. entspr. Saeure;

upstream raw materials:

3-Bromophthalide

[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid

Refernces