4,6-dichloro-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazolo[3,4-d]pyrimidine

Base Information

• Chemical Name: 4,6-dichloro-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazolo[3,4-d]pyrimidine
• CAS No.: 1037479-62-1
• Molecular Formula: C₁₀H₁₀Cl₂N₄O
• Molecular Weight: 273.122
• Mol file: 1037479-62-1.mol

Synonyms:4,6-dichloro-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazolo[3,4-d]pyrimidine

Chemical Property of 4,6-dichloro-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazolo[3,4-d]pyrimidine

Chemical Property:

Purity/Quality:

99%, ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4,6-dichloro-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazolo[3,4-d]pyrimidine

There total 9 articles about 4,6-dichloro-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazolo[3,4-d]pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

3,4-dihydro-2H-pyran (110-87-2) + 4,6-dichloro-1H-pyrazolo[3,4-d]pyrimidine (42754-96-1) → 4,6-dichloro-1-(tetrahydro-2H-pyran-2-yl)-1Hpyrazolo [3 ,4-d]pyrimidine (1037479-62-1)

Guidance literature:

With toluene-4-sulfonic acid; In tetrahydrofuran; dichloromethane; at 20 ℃;

DOI:10.1021/jm401546n

Reference yield: 53.5%

3,4-dihydro-2H-pyran (110-87-2) + 4,6-dichloro-3a,7a-dihydro-1H-pyrazolo[3,4-d]pyrimidine → 4,6-dichloro-1-(tetrahydro-2H-pyran-2-yl)-1Hpyrazolo [3 ,4-d]pyrimidine (1037479-62-1)

Guidance literature:

With toluene-4-sulfonic acid; In tetrahydrofuran; dichloromethane; at 20 ℃; for 10h;

DOI:10.1016/j.ejmech.2020.112755

Reference yield:

3,4-dihydro-2H-pyran (110-87-2) + 4,6-dichloro-1H-pyrazolo[3,4-d]pyrimidine (42754-96-1) → 4,6-dichloro-1-(tetrahydro-2H-pyran-2-yl)-1Hpyrazolo [3 ,4-d]pyrimidine (1037479-62-1) + 4,6-dichloro-2-(tetrahydro-2H-pyran-2-yl)-2H-pyrazolo[3,4-d]pyrimidine (1037479-82-5)

Guidance literature:

toluene-4-sulfonic acid; In ethyl acetate; at 20 - 50 ℃; for 1h;

upstream raw materials:

3,4-dihydro-2H-pyran

4,6-dichloro-1H-pyrazolo[3,4-d]pyrimidine

oxypurinol

2,4,6-trichloropyrimidine-5-carbaldehyde

Downstream raw materials:

6-chloro-4-(8-oxa-3-azabicyclo[3.2.1]oct-3-yl)-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazolo[3,4-d]pyrimidine

6-chloro-4-(3-nitrophenoxy)-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazolo[3,4-d]pyrimidine

N-(3-((6-((2-methoxy-4-(4-methylpiperazin-1-yl)phenyl)amino)-1H-pyrazolo[3,4-d]pyrimidin-4-yl)oxy)phenyl)acrylamide

N-(2-methoxy-4-(4-methylpiperazin-1-yl)phenyl)-4-(3-nitrophenoxy)-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazolo[3,4-d]pyrimidin-6-amine

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