(S)-4-Hydroxy Mephenytoin

Base Information

• Chemical Name: (S)-4-Hydroxy Mephenytoin
• CAS No.: 82695-93-0
• Molecular Formula: C₁₂H₁₄N₂O₃
• Molecular Weight: 234.255
• Mol file: 82695-93-0.mol

Synonyms:(S)-4-Hydroxy Mephenytoin;(5S)-5-Ethyl-5-(4-hydroxyphenyl)-3-Methyl-2,4-iMidazolidinedione;(S)-5-Ethyl-5-(4-hydroxyphenyl)-3-Methyl-2,4-iMidazolidinedione

Chemical Property of (S)-4-Hydroxy Mephenytoin

Chemical Property:

• Melting Point: 188-191°C
• PSA: 69.64000
• LogP: 1.44580
• Storage Temp.: -20°C Freezer
• Solubility.: Aqueous Base (Slightly), DMSO (Slightly), Ethyl Acetate (Slightly), Methanol （Slightly）

Purity/Quality:

97% ^*data from raw suppliers

(S)-4-HydroxyMephenytoin ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: The S-enantiomer metabolite of Mephenytoin (M225000).

Technology Process of (S)-4-Hydroxy Mephenytoin

There total 6 articles about (S)-4-Hydroxy Mephenytoin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

S-mephenytoin (70989-04-7) → [14C]-(S)-4'-Hydroxymephenytoin (61837-65-8,82695-93-0)

Guidance literature:

With β-D-glucose 6-phosphate; NADP; glucose 6-phosphate dehydrogenase; at 37 ℃; Reagent/catalyst; Enzymatic reaction;

DOI:10.2133/dmpk.DMPK-13-NT-031

Reference yield:

S-mephenytoin (70989-04-7) → (+/-)-4'-Hydroxymephenytoin (61837-65-8,82695-93-0)

Guidance literature:

With glucose-6-phosphate dehydrogenase; magnesium(II) chloride hexahydrate; human liver cytochrome P₄₅₀ isoform 2C₁₉; nicotinamide adenine dinucleotide phosphate; glucose-6-phosphate dipotassium salt; In methanol; aq. phosphate buffer; at 37 ℃; for 0.333333h; pH=7.4; Enzymatic reaction;

DOI:10.3109/00498254.2013.878815

Reference yield:

S-mephenytoin (70989-04-7) + buprenorphine hydrochloride (136232-95-6,53187-13-6,55327-62-3,64425-21-4) → [14C]-(S)-4'-Hydroxymephenytoin (61837-65-8,82695-93-0)

Guidance literature:

With CYP₂C₁₉; β-nicotinamide adenine dinucleotide phosphate sodium salt; glucose-6-phosphate dipotassium salt; glucose-6-phosphate dehydrogenase; In phosphate buffer; dimethyl sulfoxide; pH=7.4; Enzyme kinetics;

DOI:10.1248/bpb.25.682

upstream raw materials:

dimethyl sulfate

5-ethyl-5-(4-hydroxyphenyl)hydantoin

4-hydroxypropiophenone

S-mephenytoin

Refernces

• 1、 Sasabe, Hiroyuki,Koga, Toshihisa,Furukawa, Masayuki,Matsunaga, Masayuki,Sasahara, Katsunori,Hashizume, Kenta,Oozone, Yoshihiro,Amunom, Immaculate,Torii, Mikako,Umehara, Ken,Kashiyama, Eiji,Takeuchi, Kenji. "In vitro evaluations for pharmacokinetic drug-drug interactions of a novel serotonin-dopamine activity modulator, brexpiprazole". supporting information. p. 522 - 535. Retrieved 2021/03/19.
• 2、 Yang, Xin,Johnson, Nathaniel,Di, Li. "Evaluation of Cytochrome P450 Selectivity for Hydralazine as an Aldehyde Oxidase Inhibitor for Reaction Phenotyping". . p. 1627 - 1630. Retrieved 2019/01/16.