3-Pyridinecarbonyl chloride, 1,2,5,6-tetrahydro-1-methyl- (9CI)

Base Information

• Chemical Name: 3-Pyridinecarbonyl chloride, 1,2,5,6-tetrahydro-1-methyl- (9CI)
• CAS No.: 59826-28-7
• Molecular Formula: C₇H₁₀ClNO
• Molecular Weight: 159.615
• Mol file: 59826-28-7.mol

Synonyms:3-Pyridinecarbonyl chloride, 1,2,5,6-tetrahydro-1-methyl- (9CI)

Chemical Property of 3-Pyridinecarbonyl chloride, 1,2,5,6-tetrahydro-1-methyl- (9CI)

Chemical Property:

• Boiling Point: 228.1±29.0 °C(Predicted)
• PKA: 7?+-.0.40(Predicted)
• PSA: 20.31000
• Density: 1.182±0.06 g/cm3(Predicted)
• LogP: 0.95160

Purity/Quality:

99% ^*data from raw suppliers

1,2,5,6-Tetrahydro-1-methyl-3-pyridinecarbonylChloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: 1,2,5,6-Tetrahydro-1-methyl-3-pyridinecarbonyl Chloride is used in the synthesis of 6-substituted-4-(3-bromophenylamino)quinazoline derivatives which functions as irreversible inhibitor of epidermal growth factor receptor (EGFR) and human epidermal growth factor receptor (HER-2) tyrosine kinases.Also, it is an intermediate used in the synthesis of Arecaidine But-2-ynyl Ester Tosylate (A767018), which is a potent, selective mAChR M2 activator.

Technology Process of 3-Pyridinecarbonyl chloride, 1,2,5,6-tetrahydro-1-methyl- (9CI)

There total 3 articles about 3-Pyridinecarbonyl chloride, 1,2,5,6-tetrahydro-1-methyl- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-methyl-1,2,5,6-tetrahydropyridine-3-carboxylic acid (499-04-7) → 1-Methyl-1,2,5,6-tetrahydro-pyridine-3-carbonyl chloride (59826-28-7)

Guidance literature:

With thionyl chloride; for 2h; Heating;

DOI:10.1016/S0968-0896(00)00033-X

Reference yield:

arecoline (63-75-2) → 1-Methyl-1,2,5,6-tetrahydro-pyridine-3-carbonyl chloride (59826-28-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 8.2 g / water / 24 h / Heating

2: thionyl chloride / 2 h / Heating

With thionyl chloride; water; 1: Hydrolysis / 2: Chlorination;

DOI:10.1016/S0968-0896(00)00033-X

Reference yield:

arecoline hydrobromide (300-08-3) → 1-Methyl-1,2,5,6-tetrahydro-pyridine-3-carbonyl chloride (59826-28-7)

Guidance literature:

Multi-step reaction with 3 steps

1: aq. Na₂CO₃ / pH 10 - 11

2: 8.2 g / water / 24 h / Heating

3: thionyl chloride / 2 h / Heating

With thionyl chloride; water; sodium carbonate; 1: deprotonation / 2: Hydrolysis / 3: Chlorination;

DOI:10.1016/S0968-0896(00)00033-X

upstream raw materials:

1-methyl-1,2,5,6-tetrahydropyridine-3-carboxylic acid

arecoline

arecoline hydrobromide

Downstream raw materials:

arecaidine propargyl ester p-toluenesulfonate

N'-methyl-N,N-diethyl-3,4-dehydronipecotamide

C₂₈H₄₂N₄O₂

1,1-Dimethyl-3-butoxycarbonyl-1,2,5,6-tetrahydro-pyridinium-Iodid