tiraseMtiv (CK-2017357)

Base Information

Chemical Name:tiraseMtiv (CK-2017357)
CAS No.:1005491-05-3
Molecular Formula:C₁₂H₁₄N₄O
Molecular Weight:230.269
Hs Code.:
Mol file:1005491-05-3.mol

Synonyms:tiraseMtiv (CK-2017357);6-ethynyl-1-(pentan-3-yl)-1H-iMidazo[4,5-b]pyrazin-2-ol;TiraseMtiv;1-(1-Ethylpropyl)-6-ethynyl-1,3-dihydro-2H-imidazo[4,5-b]pyrazin-2-one;CK 2017357;Tirasemtiv 1-(1-Ethylpropyl)-6-ethynyl-1,3-dihydro-2H-imidazo[4,5-b]pyrazin-2-one;Tirasemtiv, >=98%

Suppliers and Price of tiraseMtiv (CK-2017357)

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
Tirasemtiv
25mg
$ 150.00

Medical Isotopes, Inc.
Tirasemtiv
25 mg
$ 650.00

Medical Isotopes, Inc.
Tirasemtiv
250 mg
$ 2200.00

Matrix Scientific
6-Ethynyl-1-(pentan-3-yl)-1H-imidazo[4,5-b]pyrazin-2-ol 97%
5mg
$ 180.00

DC Chemicals
Tirasemtiv >98%
100 mg
$ 450.00

DC Chemicals
Tirasemtiv >98%
1 g
$ 1600.00

DC Chemicals
Tirasemtiv >98%
250 mg
$ 850.00

Crysdot
Tirasemtiv(CK2017357) 98+%
250mg
$ 945.00

Crysdot
Tirasemtiv(CK2017357) 98+%
50mg
$ 315.00

Cayman Chemical
Tirasemtiv ≥98%
25mg
$ 148.00

Total 27 raw suppliers

Chemical Property of tiraseMtiv (CK-2017357)

Chemical Property:

PSA：63.57000
LogP:1.46200
Storage Temp.:-20°C Freezer
Solubility.:DMSO (Slightly), Methanol (Slightly)

Purity/Quality:

99%, ^*data from raw suppliers

Tirasemtiv ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Description Tirasemtiv is an activator of the fast skeletal troponin complex. It selectively binds to purified fast skeletal troponin complex (Kd = 40 nM) over slow skeletal (Kd = 3,800 nM) and cardiac troponin complexes. Tirasemtiv (20 μM) slows the rate of calcium release from the fast skeletal troponin complex. It increases the ATPase activity of isolated rabbit fast skeletal myofibrils at a fixed calcium concentration (EC50 = 390 nM) and sensitizes skinned fast skeletal muscle fibers isolated from human and rabbit to calcium in a concentration-dependent manner. Tirasemtiv increases in situ extensor digitorum longus (EDL) muscle force and forelimb grip strength in a rat model of myasthenia gravis. It also increases forelimb grip strength, grid hang test performance, and rotarod performance in a mouse model of amyotrophic lateral sclerosis (ALS) when administered at a dose of 10 mg/kg.
Uses Tirasemtiv is a fast skeletal muscle troponin activator and is used for treating patients with amyotrophic lateral sclerosis (ALS).

Technology Process of tiraseMtiv (CK-2017357)

There total 1 articles about tiraseMtiv (CK-2017357) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: