4'-C-azido-2'-deoxy-2'-fluoro-beta-D-arabinocytidine

Base Information

• Chemical Name: 4'-C-azido-2'-deoxy-2'-fluoro-beta-D-arabinocytidine
• CAS No.: 1011529-10-4
• Molecular Formula: C9H11FN6O4
• Molecular Weight: 286.223
• Mol file: 1011529-10-4.mol

Synonyms:4'-C-azido-2'-deoxy-2'-fluoro-beta-D-arabinocytidine;2(1H)-PyriMidinone, 4-aMino-1-(4-C-azido-2-deoxy-2-fluoro-b-D-arabinofuranosyl)-;4-Amino-1-(4-C-azido-2-deoxy-2-fluoro-beta-D-arabinofuranosyl)-2(1H)-pyrimidinone;RO 0622;4'-C-Azido-2'-deoxy-2'-fluoro-b-D-arabinocytidine

Chemical Property of 4'-C-azido-2'-deoxy-2'-fluoro-beta-D-arabinocytidine

Chemical Property:

• Melting Point: 99.0-100.0℃
• PSA: 160.35000
• LogP: -0.91384

Purity/Quality:

99% ^*data from raw suppliers

4'-C-Azido-2'-deoxy-2'-fluoro-b-D-arabinocytidine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4'-C-azido-2'-deoxy-2'-fluoro-beta-D-arabinocytidine

There total 5 articles about 4'-C-azido-2'-deoxy-2'-fluoro-beta-D-arabinocytidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

C11H13FN6O5 (1030595-44-8) → 4′-azido-2′-deoxy-2′-fluoro-β-D-arabinocytidine (1011529-10-4)

Guidance literature:

With methanol; triethylamine; at 20 ℃; for 12h;

Reference yield: 41.1%

1-(4-azido-2-deoxy-2-fluoro-3-O-benzoyl-5-O-(3-chlorobenzoyl)-β-D-arabinofuranosyl)uracil (1333126-30-9) → 4′-azido-2′-deoxy-2′-fluoro-β-D-arabinocytidine (1011529-10-4)

Guidance literature:

1-(4-azido-2-deoxy-2-fluoro-3-O-benzoyl-5-O-(3-chlorobenzoyl)-β-D-arabinofuranosyl)uracil; With pyridine; 1,2,4-Triazole; trichlorophosphate; In dichloromethane; at 0 - 20 ℃;

With ammonium hydroxide; In tetrahydrofuran; at 20 ℃; for 1h;

With ammonia; In methanol; at 20 ℃;

DOI:10.1016/j.ejmech.2011.06.020

Reference yield:

C23H18ClFN6O6 → 4′-azido-2′-deoxy-2′-fluoro-β-D-arabinocytidine (1011529-10-4)

Guidance literature:

With methanol; ammonia; at 20 ℃;

upstream raw materials:

C₁₁H₁₃FN₆O₅

1-(4-azido-2-deoxy-2-fluoro-3-O-benzoyl-5-O-(3-chlorobenzoyl)-β-D-arabinofuranosyl)uracil

Downstream raw materials:

1-[4'-(4-ethylphenyl-1,2,3-triazol-1-yl)-2'-deoxy-2'-fluoro-β-D-arabinofuranosyl]cytosine

1-[4'-(4-methylphenyl-1,2,3-triazol-1-yl)-2'-deoxy-2'-fluoro-β-D-arabinofuranosyl]cytosine

1-[4'-(4-phenyl-1,2,3-triazol-1-yl)-2'-deoxy-2'-fluoro-β-D-arabinofuranosyl]cytosine

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