2-[(6-phenyl-2,3,4,9-tetrahydro-1H-carbazol-1-yl)amino]ethanol

Base Information

• Chemical Name: 2-[(6-phenyl-2,3,4,9-tetrahydro-1H-carbazol-1-yl)amino]ethanol
• CAS No.: 425399-05-9
• Molecular Formula: C20H22N2O
• Molecular Weight: 306.4
• European Community (EC) Number: 839-822-7
• DSSTox Substance ID: DTXSID80387144
• ChEMBL ID: CHEMBL4303199
• Mol file: 425399-05-9.mol

Synonyms:2-((6-phenyl-2,3,4,9-tetrahydro-1H-carbazol-1-yl)amino)ethanol;CASIN

Chemical Property of 2-[(6-phenyl-2,3,4,9-tetrahydro-1H-carbazol-1-yl)amino]ethanol

Chemical Property:

• Boiling Point: 577.8±50.0 °C(Predicted)
• PKA: 14.76±0.10(Predicted)
• PSA: 48.05000
• Density: 1.23±0.1 g/cm3(Predicted)
• LogP: 4.18510
• Storage Temp.: 2-8°C
• Solubility.: ≥30.6 mg/mL in DMSO; insoluble in H2O; ≥19.5 mg/mL in EtOH
• XLogP3: 3.2
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 4
• Exact Mass: 306.173213330
• Heavy Atom Count: 23
• Complexity: 382

Purity/Quality:

97% ^*data from raw suppliers

CASIN ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1CC(C2=C(C1)C3=C(N2)C=CC(=C3)C4=CC=CC=C4)NCCO
• Description: The Rho family of GTPases regulates diverse signal transduction pathways. One member, the cell division control protein 42 homolog (Cdc42), is involved in filopodia function, cell polarity, cell cycling, and other processes. CASIN is an indole-based small molecule that inhibits activation of the Cdc42 GTPase (IC50 = 2 μM for inhibiting actin assembly in PIP2-stimulated actin polymerization assays). This compound has been used to explore the role of Cdc42 in the division, survival, and differentiation of hematopoietic stem cells.
• Uses: CASIN has been used as a cell division control protein 42 homolog (Cdc42) inhibitor:to study its effects on the stimulation of extracellular vesicles (EVs) in intestinal epithelial cellsto study its effects on mice jejunumto study its effects on microbial adhesion-triggered endocytosis (MATE) vesicle morphology in segmented filamentous bacteria (SFB)-colonized mice