ethyl 3,4,5-tribromopyrrole-2-carboxylate

Base Information

• Chemical Name: ethyl 3,4,5-tribromopyrrole-2-carboxylate
• CAS No.: 740813-36-9
• Molecular Formula: C7H6Br3NO2
• Molecular Weight: 375.842
• Mol file: 740813-36-9.mol

Synonyms:ethyl 3,4,5-tribromopyrrole-2-carboxylate;ethyl 3,4,5-tribromo-1H-pyrrole-2-carboxylate

Chemical Property of ethyl 3,4,5-tribromopyrrole-2-carboxylate

Chemical Property:

• PSA: 42.09000
• LogP: 3.47890

Purity/Quality:

98%,99%, ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of ethyl 3,4,5-tribromopyrrole-2-carboxylate

There total 1 articles about ethyl 3,4,5-tribromopyrrole-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

ethyl 1H-pyrrole-2-carboxylate (2199-43-1) → ethyl 3,4,5-tribromopyrrole-2-carboxylate (740813-36-9)

Guidance literature:

With N-Bromosuccinimide; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 4h; Inert atmosphere;

DOI:10.1055/a-1736-7337

Reference yield: 70.0%

ethyl 3,4,5-tribromopyrrole-2-carboxylate (740813-36-9) + 4-methylphenylboronic acid (5720-05-8) → 3,4,5-tri-p-tolyl-1H-pyrrole-2-carboxylic acid ethyl ester

Guidance literature:

With caesium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In ethanol; 1,3,5-trimethyl-benzene; Heating;

DOI:10.1055/s-2005-871939

Reference yield: 68.0%

ethyl 3,4,5-tribromopyrrole-2-carboxylate (740813-36-9) + p-tert-butylphenylboronic acid (123324-71-0) → ethyl 3,4-dibromo-5-(4-tert-butylphenyl)-1H-pyrrole-2-carboxylate

Guidance literature:

With caesium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In ethanol; 1,3,5-trimethyl-benzene; at 150 ℃; for 13h;

DOI:10.1055/s-2005-871939

upstream raw materials:

ethyl 1H-pyrrole-2-carboxylate

Downstream raw materials:

ethyl 3,4-dibromo-5-(4-isopropoxy-3-methoxyphenyl)-1H-pyrrole-2-carboxylate

ethyl 3,4-dibromo-5-(2-(2-hydroxyethyl)-4-isopropoxy-5-methoxyphenyl)-1H-pyrrole-2-carboxylate