1-Methyl-1H-imidazol-4-ylamine dihydrochloride

Base Information

• Chemical Name: 1-Methyl-1H-imidazol-4-ylamine dihydrochloride
• CAS No.: 1373223-63-2
• Molecular Formula: C4H9Cl2N3
• Molecular Weight: 170.04036
• Mol file: 1373223-63-2.mol

Synonyms:1-Methyl-1H-imidazol-4-ylamine dihydrochloride

Chemical Property of 1-Methyl-1H-imidazol-4-ylamine dihydrochloride

Chemical Property:

• PSA: 43.84000
• LogP: 2.18750

Purity/Quality:

99% ^*data from raw suppliers

1-Methyl-1H-imidazol-4-ylamine dihydrochloride 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-Methyl-1H-imidazol-4-ylamine dihydrochloride

There total 2 articles about 1-Methyl-1H-imidazol-4-ylamine dihydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

1-methyl-4-nitro-1H-imidazole (3034-41-1) → 1-methyl-1H-imidazole-4-amine hydrochloride (89088-69-7,1373223-63-2)

Guidance literature:

1-methyl-4-nitro-1H-imidazole; With hydrogen; palladium(II) hydroxide; In ethanol; at 20 ℃; for 3h;

With hydrogenchloride; In ethanol; for 0.5h;

DOI:10.1021/jm401546n

Reference yield:

1-methyl-1H-imidazol-4-amine (79578-98-6) → 1-methyl-1H-imidazole-4-amine hydrochloride (89088-69-7,1373223-63-2)

Guidance literature:

With hydrogenchloride; In ethanol; at 18 - 25 ℃; for 0.5h;

Reference yield: 32.0%

2,4-dichloro-5-[(4-methylphenyl)sulfonyl]-5H-pyrrolo[3,2-d]pyrimidine (1220517-77-0) + 1-methyl-1H-imidazole-4-amine hydrochloride (89088-69-7,1373223-63-2) → 2-chloro-N-(1-methyl-1H-imidazol-4-yl)-5-[(4-methylphenyl)sulfonyl]-5H-pyrrolo[3,2-d]pyrimidin-4-amine (1220517-78-1)

Guidance literature:

With triethylamine; In acetonitrile; at 100 ℃; for 2h; Microwave irradiation;

DOI:10.1021/jm401546n

upstream raw materials:

1-methyl-1H-imidazol-4-amine

1-methyl-4-nitro-1H-imidazole

Downstream raw materials:

2-chloro-N-(1-methyl-1H-imidazol-4-yl)-5-[(4-methylphenyl)sulfonyl]-5H-pyrrolo[3,2-d]pyrimidin-4-amine

Refernces

• 1、 Su, Qibin,Ioannidis, Stephanos,Chuaqui, Claudio,Almeida, Lynsie,Alimzhanov, Marat,Bebernitz, Geraldine,Bell, Kirsten,Block, Michael,Howard, Tina,Huang, Shan,Huszar, Dennis,Read, Jon A.,Rivard Costa, Caroline,Shi, Jie,Su, Mei,Ye, Minwei,Zinda, Michael. "Discovery of 1-methyl-1 H-imidazole derivatives as potent Jak2 inhibitors". . p. 144 - 158. Retrieved 2014/02/14.