(R)-2-ETHYLPIPERIDINE HYDROCHLORIDE

Base Information

• Chemical Name: (R)-2-ETHYLPIPERIDINE HYDROCHLORIDE
• CAS No.: 155106-15-3
• Molecular Formula: C₇H₁₅N*ClH
• Molecular Weight: 149.664
• Hs Code.: 2933399990
• Mol file: 155106-15-3.mol

Synonyms:(R)-2-ETHYLPIPERIDINE HYDROCHLORIDE

Chemical Property of (R)-2-ETHYLPIPERIDINE HYDROCHLORIDE

Chemical Property:

• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

98%,99%, ^*data from raw suppliers

(R)-2-ethylpiperidinehydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: Chiral building block developed using Liverpool ChiroChem-patented technology.

Technology Process of (R)-2-ETHYLPIPERIDINE HYDROCHLORIDE

There total 9 articles about (R)-2-ETHYLPIPERIDINE HYDROCHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

1-(3-bromopyridin-2-yl)ethanol (1383734-83-5,317845-81-1) → 2-ethylpiperidine hydrochloride (1484-99-7,155106-15-3)

Guidance literature:

With hydrogenchloride; palladium 10% on activated carbon; hydrogen; In methanol; water; at 80 ℃; for 18h; under 45004.5 Torr; Autoclave;

DOI:10.1002/ejoc.201900450

Reference yield: 88.0%

(R)-1-((R)-1-phenylethyl)-2-vinylpiperidine → (+)-(2S)-2-ethylpiperidine hydrochloride (558479-16-6,155106-15-3)

Guidance literature:

(R)-1-((R)-1-phenylethyl)-2-vinylpiperidine; With hydrogen; In methanol; at 20 ℃; for 15h; under 1900.13 Torr;

With hydrogenchloride; In water; at 20 ℃; for 1h;

DOI:10.24820/ark.5550190.p010.591

Reference yield:

3-Bromopyridine (626-55-1,163928-56-1) → 2-ethylpiperidine hydrochloride (1484-99-7,155106-15-3)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 2,2,6,6-tetramethylpiperidinylmagnesium chloride lithium chloride complex / tetrahydrofuran / 3 h / 0 °C

1.2: 1.5 h / 20 °C

2.1: palladium 10% on activated carbon; hydrogenchloride; hydrogen / methanol; water / 18 h / 80 °C / 45004.5 Torr / Autoclave

With hydrogenchloride; 2,2,6,6-tetramethylpiperidinylmagnesium chloride lithium chloride complex; palladium 10% on activated carbon; hydrogen; In tetrahydrofuran; methanol; water;

DOI:10.1002/ejoc.201900450

upstream raw materials:

1-(3-bromopyridin-2-yl)ethanol

3-Bromopyridine

ethyl 5-bromovalerate

5-bromopentanal

Downstream raw materials:

(2S)-ethyl-1-[(R)-oxiranylmethyl] piperidine

Refernces

• 1、 Olszewska, Beata,Jablonska, Aleksandra,Zawisza, Anna. "Diastereoselective synthesis of 2-vinylpyrrolidines and 2-vinylpiperidines by the palladium-catalysed cyclization of amino-allylic carbonates containing a chiral protecting group". . p. 254 - 271. Retrieved 2018/09/10.