MethanesulfonaMide, N-[3-[[[2-[(2,3-dihydro-2-oxo-1H-indol-5-yl)aMino]-5-(trifluoroMethyl)-4-pyriMidinyl]aMino]Methyl]-2-pyridinyl]-N-Methyl-, hydrochloride (1:1)

Base Information

Chemical Name:MethanesulfonaMide, N-[3-[[[2-[(2,3-dihydro-2-oxo-1H-indol-5-yl)aMino]-5-(trifluoroMethyl)-4-pyriMidinyl]aMino]Methyl]-2-pyridinyl]-N-Methyl-, hydrochloride (1:1)
CAS No.:939791-41-0
Molecular Formula:C₂₁H₂₀F₃N₇O₃S*ClH
Molecular Weight:543.957
Hs Code.:

MethanesulfonaMide, N-[3-[[[2-[(2,3-dihydro-2-oxo-1H-indol-5-yl)aMino]-5-(trifluoroMethyl)-4-pyriMidinyl]aMino]Methyl]-2-pyridinyl]-N-Methyl-, hydrochloride (1:1)

Synonyms:MethanesulfonaMide, N-[3-[[[2-[(2,3-dihydro-2-oxo-1H-indol-5-yl)aMino]-5-(trifluoroMethyl)-4-pyriMidinyl]aMino]Methyl]-2-pyridinyl]-N-Methyl-, hydrochloride (1:1)

Suppliers and Price of MethanesulfonaMide, N-[3-[[[2-[(2,3-dihydro-2-oxo-1H-indol-5-yl)aMino]-5-(trifluoroMethyl)-4-pyriMidinyl]aMino]Methyl]-2-pyridinyl]-N-Methyl-, hydrochloride (1:1)

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 6 raw suppliers

Chemical Property of MethanesulfonaMide, N-[3-[[[2-[(2,3-dihydro-2-oxo-1H-indol-5-yl)aMino]-5-(trifluoroMethyl)-4-pyriMidinyl]aMino]Methyl]-2-pyridinyl]-N-Methyl-, hydrochloride (1:1)

Chemical Property:

Purity/Quality:: 97% ^*data from raw suppliers

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Technology Process of MethanesulfonaMide, N-[3-[[[2-[(2,3-dihydro-2-oxo-1H-indol-5-yl)aMino]-5-(trifluoroMethyl)-4-pyriMidinyl]aMino]Methyl]-2-pyridinyl]-N-Methyl-, hydrochloride (1:1)

There total 5 articles about MethanesulfonaMide, N-[3-[[[2-[(2,3-dihydro-2-oxo-1H-indol-5-yl)aMino]-5-(trifluoroMethyl)-4-pyriMidinyl]aMino]Methyl]-2-pyridinyl]-N-Methyl-, hydrochloride (1:1) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 717907-75-0
PF-562,271

: 939791-41-0
N-methyl-N-{3-[({2-[(2-oxo-2,3-dihydro-1H-indol-5-yl)amino]-5-(trifluoromethyl)-4-pyrimidinyl}amino)methyl]-2-pyridinyl}methanesulfonamide hydrochloride

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; ethanol; at 20 ℃; for 168h; Product distribution / selectivity;

Reference yield:

: 3932-97-6
2,4-dichloro-5-trifluoromethylpyrimidine

: 939791-41-0
N-methyl-N-{3-[({2-[(2-oxo-2,3-dihydro-1H-indol-5-yl)amino]-5-(trifluoromethyl)-4-pyrimidinyl}amino)methyl]-2-pyridinyl}methanesulfonamide hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1.1: zinc dibromide / 1,2-dichloro-ethane; tert-butyl alcohol / 0.5 h

1.2: 35 °C / Industry scale

2.1: diisopropylamine / isopropyl alcohol; toluene / 6.4 h / 10 - 90 °C / Industry scale

3.1: hydrogenchloride / 1,4-dioxane; ethanol / 168 h / 20 °C

With hydrogenchloride; diisopropylamine; zinc dibromide; In 1,4-dioxane; ethanol; 1,2-dichloro-ethane; isopropyl alcohol; toluene; tert-butyl alcohol;

Reference yield:

: 54-20-6
5-trifluoromethyluracil

: 939791-41-0
N-methyl-N-{3-[({2-[(2-oxo-2,3-dihydro-1H-indol-5-yl)amino]-5-(trifluoromethyl)-4-pyrimidinyl}amino)methyl]-2-pyridinyl}methanesulfonamide hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1.1: N-ethyl-N,N-diisopropylamine; trichlorophosphate; phosphoric acid / water / 22 h / 20 - 100 °C / Industry scale

2.1: zinc dibromide / 1,2-dichloro-ethane; tert-butyl alcohol / 0.5 h

2.2: 35 °C / Industry scale

3.1: diisopropylamine / isopropyl alcohol; toluene / 6.4 h / 10 - 90 °C / Industry scale

4.1: hydrogenchloride / 1,4-dioxane; ethanol / 168 h / 20 °C

With hydrogenchloride; phosphoric acid; diisopropylamine; N-ethyl-N,N-diisopropylamine; zinc dibromide; trichlorophosphate; In 1,4-dioxane; ethanol; water; 1,2-dichloro-ethane; isopropyl alcohol; toluene; tert-butyl alcohol;