TN ANTIGEN

Base Information

• Chemical Name: TN ANTIGEN
• CAS No.: 67262-86-6
• Molecular Formula: C₁₁H₂₀N₂O₈
• Molecular Weight: 308.288
• Mol file: 67262-86-6.mol

Synonyms:GALNAC-ALPHA1-O-SER;SERINYL 2-ACETAMIDO-2-DEOXY-A-GALACTOPYRANOSIDE;N-ACETYLGALACTOSAMINE, ALPHA1-O-SERINE;N-ACETYL-ALPHA-D-GALACTOSAMINYL-1-O-SERINE;TN EPITOPE;TN ANTIGEN;Serinyl 2-acetamido-2-deoxy-a-galactopyranoside, N-acetyl-a-D-galactosaminyl-1-O-serine;Serinyl 2-acetamido-2-deoxy-α-galactopyranoside, N-acetyl-α-D-galactosaminyl-1-O-serine

Chemical Property of TN ANTIGEN

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Melting Point: 198-201°C
• Boiling Point: 701.205°C at 760 mmHg
• PKA: 2.05±0.10(Predicted)
• Flash Point: 377.875°C
• PSA: 171.57000
• Density: 1.517g/cm³
• LogP: -2.55020
• Storage Temp.: Hygroscopic, -20°C Freezer, Under Inert Atmosphere
• Solubility.: Water

Purity/Quality:

98%,99%, ^*data from raw suppliers

Tn Epitope ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: A cancer associated carbohydrate tumor antigen which may be effective as cancer specific targets for immunotherapy as well as in the development of diagnostic monoclonal antibodies. Has been used or considered for use in human vaccines. TN ANTIGEN is a cancer associated carbohydrate tumor antigen which may be effective as cancer specific targets for immunotherapy as well as in the development of diagnostic monoclonal antibodies. Has been used or considered for use in human vaccines

Technology Process of TN ANTIGEN

There total 16 articles about TN ANTIGEN which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

3-O-(2-Acetamido-2-desoxy-α-D-galactopyranosyl)-N-(benzyloxycarbonyl)-L-serinbenzylester (83956-38-1) → 3-O-(2-Acetamido-2-desoxy-α-D-galactopyranosyl)-L-serin (17041-36-0,72259-90-6,116949-18-9,67262-86-6)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol; acetic acid; for 4h; Ambient temperature;

DOI:10.1016/0008-6215(82)84033-0

Reference yield: 94.0%

O-(2-acetamido-3,4,6-tri-O-acetyl-2-deoxy-α-D-galactopyranosyl)-L-serine (83956-40-5) → 3-O-(2-Acetamido-2-desoxy-α-D-galactopyranosyl)-L-serin (17041-36-0,72259-90-6,116949-18-9,67262-86-6)

Guidance literature:

With methanol; sodium methylate; for 2h; Ambient temperature;

DOI:10.1016/0008-6215(82)84033-0

Reference yield: 93.0%

Nα-(fluoren-9-ylmethoxycarbonyl)-3-O-(3,4,6-tri-O-acetyl-2-acetamido-2-deoxy-α-D-galactopyranosyl)-L-serine allyl ester (136497-88-6) → 3-O-(2-Acetamido-2-desoxy-α-D-galactopyranosyl)-L-serin (17041-36-0,72259-90-6,116949-18-9,67262-86-6)

Guidance literature:

With methanol; triethylamine; sodium hydroxide; Inert atmosphere;

DOI:10.1016/j.carres.2016.10.008

upstream raw materials:

O-(2-acetamido-3,4,6-tri-O-acetyl-2-deoxy-α-D-galactopyranosyl)-L-serine

3-O-(2-Acetamido-2-desoxy-α-D-galactopyranosyl)-N-(benzyloxycarbonyl)-L-serinbenzylester

O-(3,4,6-tri-O-acetyl-2-azido-2-deoxy-α-D-galactopyranosyl)-N-benzyloxycarbonyl-L-serine benzyl ester

3,4,6-tri-O-acetyl-2-azido-2-deoxy-β-D-galactopyranosyl trichloroacetimidate

Downstream raw materials:

3-O-(2-acetamido-2-deoxy-3-O-β-D-galactopyranosyl-α-D-galactopyranosyl)-L-serine

N-(benzyloxycarbonyl)-O-(2-acetamido-2-deoxy-α-D-galactopyranosyl)-(1->3)-L-serine allyl ester

N-(benzyloxycarbonyl)-O-(β-D-galactopyranosyl)-(1->3)-O-(2-acetamido-2-deoxy-α-D-galactopyranosyl)-(1->3)-L-serine allyl ester

N-(benzyloxycarbonyl)-O-(3,4-O-isopropylidene-β-D-galactopyranosyl)-(1->3)-O-(2-acetamido-2-deoxy-4,6-O-isopropylidene-α-D-galactopyranosyl)-(1->3)-L-serine allyl ester

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