3-CARBOXYMETHYL-MORPHOLINE-4-CARBOXYLIC ACID BENZYL ESTER

Base Information

• Chemical Name: 3-CARBOXYMETHYL-MORPHOLINE-4-CARBOXYLIC ACID BENZYL ESTER
• CAS No.: 885273-93-8
• Molecular Formula: C₁₄H₁₇NO₅
• Molecular Weight: 279.293
• Hs Code.: 2934999090
• Mol file: 885273-93-8.mol

Synonyms:4-CBZ-3-CARBOXYMETHYL-MORPHOLINE;3-CARBOXYMETHYL-MORPHOLINE-4-CARBOXYLIC ACID BENZYL ESTER;4-Cbz-3-morpholineacetic acid

Chemical Property of 3-CARBOXYMETHYL-MORPHOLINE-4-CARBOXYLIC ACID BENZYL ESTER

Chemical Property:

• PSA: 76.07000
• LogP: 1.43660

Purity/Quality:

98%min ^*data from raw suppliers

4-Cbz-3-carboxymethyl-morpholine 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-CARBOXYMETHYL-MORPHOLINE-4-CARBOXYLIC ACID BENZYL ESTER

There total 4 articles about 3-CARBOXYMETHYL-MORPHOLINE-4-CARBOXYLIC ACID BENZYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

benzyl 3-(2-methoxy-2-oxoethyl)morpholine-4-carboxylate → 2-(4-((benzyloxy)carbonyl)morpholin-3-yl)acetic acid (885273-93-8)

Guidance literature:

With lithium hydroxide monohydrate; In methanol; water; at 20 - 50 ℃; for 2h;

Reference yield:

2,2-dimethyl-5-(morpholin-3-ylidene)-1,3-dioxane-4,6-dione → 2-(4-((benzyloxy)carbonyl)morpholin-3-yl)acetic acid (885273-93-8)

Guidance literature:

Multi-step reaction with 4 steps

1: methanol / 2 h / Reflux

2: sodium tetrahydroborate; acetic acid / 1,4-dioxane / 0.33 h / 20 °C

3: sodium hydrogencarbonate / tetrahydrofuran / 1 h / 20 °C

4: lithium hydroxide monohydrate / methanol; water / 2 h / 20 - 50 °C

With sodium tetrahydroborate; lithium hydroxide monohydrate; sodium hydrogencarbonate; acetic acid; In tetrahydrofuran; 1,4-dioxane; methanol; water;

Reference yield:

(Z)-methyl 2-(morpholin-3-ylidene)acetate → 2-(4-((benzyloxy)carbonyl)morpholin-3-yl)acetic acid (885273-93-8)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium tetrahydroborate; acetic acid / 1,4-dioxane / 0.33 h / 20 °C

2: sodium hydrogencarbonate / tetrahydrofuran / 1 h / 20 °C

3: lithium hydroxide monohydrate / methanol; water / 2 h / 20 - 50 °C

With sodium tetrahydroborate; lithium hydroxide monohydrate; sodium hydrogencarbonate; acetic acid; In tetrahydrofuran; 1,4-dioxane; methanol; water;

upstream raw materials:

2-(morpholin-3-yl)ethanoic acid methyl ester

Refernces