7-Chloro-6-fluoro indole

Base Information

• Chemical Name: 7-Chloro-6-fluoro indole
• CAS No.: 259860-01-0
• Molecular Formula: C8H5ClFN
• Molecular Weight: 169.5834032
• Mol file: 259860-01-0.mol

Synonyms:7-Chloro-6-fluoro indole;7-Chloro-5-fluoro-1H-indole

Chemical Property of 7-Chloro-6-fluoro indole

Chemical Property:

• PSA: 15.79000
• LogP: 2.96040

Purity/Quality:

98%,99%, ^*data from raw suppliers

7-Chloro-5-fluoro-1H-indole 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 7-Chloro-6-fluoro indole

There total 5 articles about 7-Chloro-6-fluoro indole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

methyl (2-chloro-4-fluoro-6-((trimethyl silyl)ethynyl)phenyl)carbamate → 7-chloro-5-fluoro-1H-indole (259860-01-0)

Guidance literature:

With sodium ethanolate; In ethanol; at 20 ℃; for 4h; Inert atmosphere; Reflux;

Reference yield: 37.0%

7-chloro-5-fluoroindole-2,3-dione (259860-03-2) → 7-chloro-5-fluoro-1H-indole (259860-01-0)

Guidance literature:

With sodium hydroxide; In tetrahydrofuran; water;

Reference yield:

methyl (2-bromo-6-chloro-4-fluorophenyl)carbamate → 7-chloro-5-fluoro-1H-indole (259860-01-0)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide / acetonitrile / 3 h / Reflux; Inert atmosphere

2: sodium ethanolate / ethanol / 4 h / 20 °C / Inert atmosphere; Reflux

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; sodium ethanolate; triethylamine; In ethanol; acetonitrile;

upstream raw materials:

7-chloro-5-fluoroindole-2,3-dione

2-bromo-6-chloro-4-fluorophenylamine

Refernces

• 1、 -. "Indoline derivatives as 5-HT2B and or 5-HTC receptor ligands". . . Retrieved 2008/06/13.