BI-847325

Base Information

Chemical Name:BI-847325
CAS No.:1207293-36-4
Molecular Formula:C29H28N4O2
Molecular Weight:464.56
Hs Code.:
Mol file:1207293-36-4.mol

Synonyms:BI-847325;3-[3-[[[4-[(Dimethylamino)methyl]phenyl]amino]phenylmethylene]-2,3-dihydro-2-oxo-1H-indol-6-yl]-N-ethyl-2-propynamide

Suppliers and Price of BI-847325

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
BI-847325
100mg
$ 1240.00

DC Chemicals
BI-847325 >98%
1 g
$ 1800.00

Crysdot
BI-847325 95+%
25mg
$ 366.00

Crysdot
BI-847325 95+%
50mg
$ 607.00

Crysdot
BI-847325 95+%
100mg
$ 817.00

ChemScene
BI-847325 99.14%
25mg
$ 432.00

ChemScene
BI-847325 99.14%
100mg
$ 1056.00

ChemScene
BI-847325 99.14%
50mg
$ 756.00

ChemScene
BI-847325 99.14%
10mg
$ 216.00

ChemScene
BI-847325 99.14%
5mg
$ 132.00

Total 18 raw suppliers

Chemical Property of BI-847325

Chemical Property:

PSA：73.47000
LogP:4.77020
Solubility.:≥24.1 mg/mL in DMSO; insoluble in EtOH; insoluble in H2O

Purity/Quality:

99%, ^*data from raw suppliers

BI-847325 ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Description BI-847325 is a selective dual MEK/Aurora kinase inhibitor with IC50 values of 3, 25, 15, 25, and 4 nM for X. laevis Aurora B, human Aurora A and Aurora C, and human MEK1 and MEK2, respectively. It can inhibit the growth and survival of both treatment-naive and drug-resistant melanoma cell lines, decreasing the expression of MEK and Mcl-1 while increasing the expression of pro-apoptotic protein Bim. At 70 mg/kg, BI-847325 induces apoptosis in treatment-naive and drug-resistant xenografted melanoma in vivo.
Uses BI-847325 is a novel ATP-competitive MEK and Aurora kinase inhibitor. It can inhibit the growth of BRAF resistant melanoma cells through suppression of Mcl-1 and MEK expression in human melanoma cell lines and mouse xenograft model. The efficacy of BI-847325 was studied in patients with refractory solid tumors.

Technology Process of BI-847325

There total 1 articles about BI-847325 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: