4-(4-CHLORO-PHENYL)-5-METHYL-2H-PYRAZOL-3-YLAMINE

Base Information

• Chemical Name: 4-(4-CHLORO-PHENYL)-5-METHYL-2H-PYRAZOL-3-YLAMINE
• CAS No.: 214416-39-4
• Molecular Formula: C10H10ClN3
• Molecular Weight: 207.662
• Hs Code.: 2933199090
• Mol file: 214416-39-4.mol

Synonyms:4-(4-CHLOROPHENYL)-3-METHYL-1H-PYRAZOL-5-AMINE;4-(4-CHLORO-PHENYL)-5-METHYL-2H-PYRAZOL-3-YLAMINE;AKOS BBS-00005783;ASISCHEM C58484;TIMTEC-BB SBB011182;4-(4-chlorophenyl)-3-methyl-1H-pyrazol-5-amine(SALTDATA: FREE);[4-(4-chlorophenyl)-5-methyl-1H-pyrazol-3-yl]amine;4-(4-chlorophenyl)-5-methyl-1H-pyrazol-3-amine

Chemical Property of 4-(4-CHLORO-PHENYL)-5-METHYL-2H-PYRAZOL-3-YLAMINE

Chemical Property:

• PSA: 54.70000
• LogP: 3.20190

Purity/Quality:

98%min ^*data from raw suppliers

4-(4-chlorophenyl)-3-methyl-1H-pyrazol-5-amine ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xn
• Statements: 22

MSDS Files:

Useful:

Technology Process of 4-(4-CHLORO-PHENYL)-5-METHYL-2H-PYRAZOL-3-YLAMINE

There total 6 articles about 4-(4-CHLORO-PHENYL)-5-METHYL-2H-PYRAZOL-3-YLAMINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

2-(4-chlorophenyl)-3-oxobutanenitrile (5219-07-8) → 3-methyl-4-(4-chlorophenyl)-1H-pyrazol-5-amine (214416-39-4)

Guidance literature:

With hydrazine hydrate; acetic acid; In toluene; at 105 ℃; for 14h;

Reference yield: 81.0%

N,N-dimethylacetamide dimethyl acetal (18871-66-4) + p-chlorobenzyl cyanide (140-53-4) → 3-methyl-4-(4-chlorophenyl)-1H-pyrazol-5-amine (214416-39-4)

Guidance literature:

N,N-dimethylacetamide dimethyl acetal; p-chlorobenzyl cyanide; In dichloromethane; at 100 ℃; for 24h; Sealed tube; Inert atmosphere; Microwave irradiation;

With hydrazine hydrochloride; In ethanol; water; at 80 ℃; for 12h;

DOI:10.1021/acs.jmedchem.7b00304

Reference yield:

2-(4-chlorophenyl)-3-oxobutanenitrile (5219-07-8) → 4-(4-chlorophenyl)-5-methyl-1H-pyrazol-3-amine (214416-39-4)

Guidance literature:

With hydrazine hydrate; acetic acid; In ethanol; at 50 ℃; for 7h; Reflux;

DOI:10.1134/S1070428014030191

upstream raw materials:

2-(4-chlorophenyl)-3-oxobutanenitrile

p-chlorobenzyl cyanide

N,N-dimethylacetamide dimethyl acetal

Downstream raw materials:

3-(4-chloro-phenyl)-5-methoxymethyl-2-methyl-pyrazolo[1,5-a]pyrimidin-7-ol

3-(4-chloro-phenyl)-5-ethyl-2-methyl-pyrazolo[1,5-a]pyrimidin-7-ol

7-chloro-3-(4-chloro-phenyl)-2,5-dimethyl-pyrazolo[1,5-a]pyrimidine

3-(4-chlorophenyl)-2,5-dimethyl-6,7,8,9-tetrahydropyrazolo[1,5-a]quinazoline