3-Bromo-5-(4-methoxyphenoxy)pyridine

Base Information

• Chemical Name: 3-Bromo-5-(4-methoxyphenoxy)pyridine
• CAS No.: 374934-98-2
• Molecular Formula: C12H10BrNO2
• Molecular Weight: 280.1173
• Hs Code.: 2933399090
• Mol file: 374934-98-2.mol

Synonyms:3-Bromo-5-(4-methoxyphenoxy)pyridine;Pyridine, 3-broMo-5-(4-Methoxyphenoxy)-

Chemical Property of 3-Bromo-5-(4-methoxyphenoxy)pyridine

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Boiling Point: 351.545°C at 760 mmHg
• Flash Point: 166.408°C
• PSA: 31.35000
• Density: 1.448g/cm³
• LogP: 3.64500

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-Bromo-5-(4-methoxyphenoxy)pyridine

There total 1 articles about 3-Bromo-5-(4-methoxyphenoxy)pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ 3-bromo-5-(4-methoxyphenoxy)pyridine (374934-98-2)

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; at 0 - 25 ℃; for 0.5h; Inert atmosphere;

In N,N-dimethyl-formamide; at 100 ℃; for 12h;

Reference yield: 72.0%

3-bromo-5-(4-methoxyphenoxy)pyridine (374934-98-2) → C12H10FNO2

Guidance literature:

With potassium fluoride; C₁₁₄H₁₅₈O₄P₂Pd₂; silver fluoride; In 2-methyltetrahydrofuran; at 150 ℃; for 14h; Sealed tube;

DOI:10.1021/ja5009739

Reference yield:

3-bromo-5-(4-methoxyphenoxy)pyridine (374934-98-2) + tert-butyl 7-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3-azabicyclo[3.3.1]non-7-ene-3-carboxylate (909135-34-8) → 7-(5-(4-methoxyphenoxy)pyridin-3-yl)-3-azabicyclo[3.3.1]non-7-ene trifluoroacetate

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate; palladium diacetate; 1,1'-bis-(diphenylphosphino)ferrocene / 1,2-dimethoxyethane; water / 0.15 h / 106 °C / Inert atmosphere

2: dichloromethane / 1 h

With 1,1'-bis-(diphenylphosphino)ferrocene; palladium diacetate; potassium carbonate; In 1,2-dimethoxyethane; dichloromethane; water; 1: |Suzuki Coupling;

DOI:10.1021/jm3011299

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