Dehydroepiandrosterone-D5 (DHEA-D5) (2,2,3,4,4-D5)

Base Information

• Chemical Name: Dehydroepiandrosterone-D5 (DHEA-D5) (2,2,3,4,4-D5)
• CAS No.: 97453-25-3
• Molecular Formula: C₁₉H₂₈O₂
• Molecular Weight: 293.39
• Mol file: 97453-25-3.mol

Synonyms:Dehydroepiandrosterone-D5 (DHEA-D5) (2,2,3,4,4-D5);Dehydroepiandrosterone-d5;Sodium Prasterone Sulfate-d4;Dehydroepiandrosterone-d5 (2,2,3,4,4-d5);Dehydroepiandrosterone-D5 (DHEA-D5) (2,2,3,4,4-D5) solution;DHEAS-D5 (2,2,3,4,4-D5);Dehydroepiandrosterone-D5-3-sulfate (DHEAS-D5) (2,2,3,4,4,-D5) sodium salt solution;Dehydroepiandrosterone-d5-3-sulfate sodium salt (2,2,3,4,4,-d5)

Chemical Property of Dehydroepiandrosterone-D5 (DHEA-D5) (2,2,3,4,4-D5)

Chemical Property:

• Flash Point: 9 °C
• PSA: 37.30000
• LogP: 3.87920
• Storage Temp.: 2-8°C

Purity/Quality:

CP: 97%; Enrichment: 98% ^*data from raw suppliers

Dehydroepiandrosterone-D5-3-sulfate (DHEAS-D5) (2,2,3,4,4,-D5) sodium salt solution 100?μg/mL in methanol (as free sulfate), ampule of 1?mL, certified reference material, Cerilliant? ^*data from reagent suppliers

Safty Information:

• Hazard Codes: F,T
• Statements: 11-23/24/25-39/23/24/25
• Safety Statements: 7-16-36/37-45

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Dehydroepiandrosterone-d5 is the labeled analogue of Dehydro Epiandrosterone (D229585). Dehydro Epiandrosterone is a major secretory steroidal product of the adrenal gland; secretion progresively declines with aging. May have estrogen-or androgen-like effects depending on the hormonal milieu. Intracellularly converted to androstenedione. It is used in treatment of menopausal syndrome. Dehydroepiandrosterone-d5 can be used as an active agent in the preparation of a pharmaceutical for the treatment of asthma or other respiratory diseases.

Technology Process of Dehydroepiandrosterone-D5 (DHEA-D5) (2,2,3,4,4-D5)

There total 3 articles about Dehydroepiandrosterone-D5 (DHEA-D5) (2,2,3,4,4-D5) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C21H27(2)H5O3 → 3β-hydroxy-5-androsten-17-one-2,2,3α,4,4-d5 (97453-25-3)

Guidance literature:

With hydrogenchloride; In water; for 5h; Yield given; Ambient temperature;

Reference yield:

(8R,9S,10R,13S,14S)-10,13-dimethyl-1,6,7,8,9,10,11,12,13,14,15,16-dodecahydrospiro[cyclopenta[a]phenanthrene-17,2'-[1,3]dioxolan]-3(2H)-one (14456-13-4) → 3β-hydroxy-5-androsten-17-one-2,2,3α,4,4-d5 (97453-25-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 1.) tert-BuOK; 2.) AcOD / 1.) tert-BuOH, room temp., 2 h

2: LiAlD₄ / 2-methyl-propan-2-ol; tetrahydrofuran / 0 deg C, 30 min, then room temp., 2 h

3: 10percent HCl / H₂O / 5 h / Ambient temperature

With hydrogenchloride; lithium aluminium deuteride; deuteroacetic acid; potassium tert-butylate; In tetrahydrofuran; water; tert-butyl alcohol;

Reference yield:

C21H26(2)H4O3 (97453-26-4) → 3β-hydroxy-5-androsten-17-one-2,2,3α,4,4-d5 (97453-25-3)

Guidance literature:

Multi-step reaction with 2 steps

1: LiAlD₄ / 2-methyl-propan-2-ol; tetrahydrofuran / 0 deg C, 30 min, then room temp., 2 h

2: 10percent HCl / H₂O / 5 h / Ambient temperature

With hydrogenchloride; lithium aluminium deuteride; In tetrahydrofuran; water; tert-butyl alcohol;

upstream raw materials:

(8R,9S,10R,13S,14S)-10,13-dimethyl-1,6,7,8,9,10,11,12,13,14,15,16-dodecahydrospiro[cyclopenta[a]phenanthrene-17,2'-[1,3]dioxolan]-3(2H)-one

C₂₁H₂₆⁽²⁾H₄O₃

Refernces