(5S)-N6-[(5S)-5-AMino-5-carboxypentyl]-5-hydroxy-L-lysine Trihydrochloride

Base Information

• Chemical Name: (5S)-N6-[(5S)-5-AMino-5-carboxypentyl]-5-hydroxy-L-lysine Trihydrochloride
• CAS No.: 869111-61-5
• Molecular Formula: C₁₂H₂₅N₃O₅*3ClH
• Molecular Weight: 400.73
• Mol file: 869111-61-5.mol

Synonyms:(2S,2'S,5S)-5-Hydroxy Lysinonorleucine Hydrochloride;(5S)-N6-[(5S)-5-AMino-5-carboxypentyl]-5-hydroxy-L-lysine Trihydrochloride

Chemical Property of (5S)-N6-[(5S)-5-AMino-5-carboxypentyl]-5-hydroxy-L-lysine Trihydrochloride

Chemical Property:

Purity/Quality:

(2S,2??S,5S)-5-HydroxyLysinonorleucineHCl ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: 2S,2’S,5S)-5-Hydroxy Lysinonorleucine is one of the stereoisomers of 5-Hydroxylysinonorleucine, reduced collagen cross links.

Technology Process of (5S)-N6-[(5S)-5-AMino-5-carboxypentyl]-5-hydroxy-L-lysine Trihydrochloride

There total 4 articles about (5S)-N6-[(5S)-5-AMino-5-carboxypentyl]-5-hydroxy-L-lysine Trihydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(2S,5R)-2-Amino-6-((S)-5-amino-5-tert-butoxycarbonyl-pentylamino)-5-hydroxy-hexanoic acid → (2S,5R)-2-amino-6-[(5S)-5-amino-5-carboxypentylamino]-5-hydroxyhexanoic acid trihydrochloride (869111-61-5)

Guidance literature:

With hydrogenchloride; In water; at 20 ℃; for 2h;

DOI:10.1016/j.tetasy.2005.08.023

Reference yield:

(2S,5S)-2-Amino-6-((S)-5-amino-5-tert-butoxycarbonyl-pentylamino)-5-hydroxy-hexanoic acid → (2S,5S)-2-amino-6-[(5S)-5-amino-5-carboxypentylamino]-5-hydroxyhexanoic acid trihydrochloride (869111-61-5)

Guidance literature:

With hydrogenchloride; In water; at 20 ℃; for 2h;

DOI:10.1016/j.tetasy.2005.08.023

Reference yield:

(3S,5S,6R)-3-[(S)-4-((S)-5-Benzyloxycarbonylamino-5-tert-butoxycarbonyl-pentylamino)-3-hydroxy-butyl]-2-oxo-5,6-diphenyl-morpholine-4-carboxylic acid tert-butyl ester (869111-59-1) → (2S,5S)-2-amino-6-[(5S)-5-amino-5-carboxypentylamino]-5-hydroxyhexanoic acid trihydrochloride (869111-61-5)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium; liquid ammonia / tetrahydrofuran; ethanol / 0.33 h / -40 °C

2: 37 mg / HCl / H₂O / 2 h / 20 °C

With hydrogenchloride; ammonia; sodium; In tetrahydrofuran; ethanol; water;

DOI:10.1016/j.tetasy.2005.08.023

upstream raw materials:

(3S,5S,6R)-3-[(S)-4-((S)-5-Benzyloxycarbonylamino-5-tert-butoxycarbonyl-pentylamino)-3-hydroxy-butyl]-2-oxo-5,6-diphenyl-morpholine-4-carboxylic acid tert-butyl ester

(3S,5S,6R)-3-[(R)-4-((S)-5-Benzyloxycarbonylamino-5-tert-butoxycarbonyl-pentylamino)-3-hydroxy-butyl]-2-oxo-5,6-diphenyl-morpholine-4-carboxylic acid tert-butyl ester