(3R,4R)-1-Benzyl-4-(trifluoromethyl)tetrahydro-1H-pyrrole-3-carboxylic acid

Base Information

• Chemical Name: (3R,4R)-1-Benzyl-4-(trifluoromethyl)tetrahydro-1H-pyrrole-3-carboxylic acid
• CAS No.: 184844-96-0
• Molecular Formula: C13H14F3NO2
• Molecular Weight: 273.2509696
• Hs Code.: 2916399090
• Mol file: 184844-96-0.mol

Synonyms:(3R,4R)-1-Benzyl-4-(trifluoromethyl)tetrahydro-1H-pyrrole-3-carboxylic acid

Chemical Property of (3R,4R)-1-Benzyl-4-(trifluoromethyl)tetrahydro-1H-pyrrole-3-carboxylic acid

Chemical Property:

• Melting Point: 92℃(dec)
• PSA: 40.54000
• LogP: 2.31940

Purity/Quality:

98%min ^*data from raw suppliers

(3R,4R)-1-Benzyl-4-(trifluoromethyl)pyrrolidine-3-carboxylic acid 95.0% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
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MSDS Files:

SDS file from LookChem

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Technology Process of (3R,4R)-1-Benzyl-4-(trifluoromethyl)tetrahydro-1H-pyrrole-3-carboxylic acid

There total 4 articles about (3R,4R)-1-Benzyl-4-(trifluoromethyl)tetrahydro-1H-pyrrole-3-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

trans-1-benzyl-4-trifluoromethylpyrrolidine-3-carboxylic acid ethyl ester (217096-03-2) → C15H18F3NO2 (217096-03-2) + (3R,4R)-1-Benzyl-4-trifluoromethyl-pyrrolidine-3-carboxylic acid (184844-96-0,169750-31-6)

Guidance literature:

trans-1-benzyl-4-trifluoromethylpyrrolidine-3-carboxylic acid ethyl ester; With CAL B lipase; phosphoric acid; In water; at 35 ℃; for 0.25h;

With potassium phosphate; In water; for 42h;

DOI:10.1021/acs.jmedchem.5b01633

Reference yield:

N-benzyl-N-(methoxymethyl)-N-[(trimethylsilyl)methyl]amine (93102-05-7) → (3R,4R)-1-Benzyl-4-trifluoromethyl-pyrrolidine-3-carboxylic acid (184844-96-0,169750-31-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 95 percent / TFA / CH₂Cl₂

2: 92 percent / NaOH / methanol

With sodium hydroxide; trifluoroacetic acid; In methanol; dichloromethane;

DOI:10.1016/S0960-894X(98)00514-9

Reference yield:

ethyl (+/-)-(3R,4R)-1-benzyl-4-(trifluoromethyl)pyrrolidine-3-carboxylate (152188-51-7,217096-03-2) → (3R,4R)-1-Benzyl-4-trifluoromethyl-pyrrolidine-3-carboxylic acid (184844-96-0,169750-31-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 92 percent / NaOH / methanol

With sodium hydroxide; In methanol;

DOI:10.1016/S0960-894X(98)00514-9

upstream raw materials:

(3S,4S)-1-Benzyl-4-trifluoromethyl-pyrrolidine-3-carboxylic acid

N-benzyl-N-(methoxymethyl)-N-[(trimethylsilyl)methyl]amine

ethyl (+/-)-(3R,4R)-1-benzyl-4-(trifluoromethyl)pyrrolidine-3-carboxylate

trans-1-benzyl-4-trifluoromethylpyrrolidine-3-carboxylic acid ethyl ester

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