Pyridine, 4-broMo-2,6-bis(trifluoroMethyl)-

Base Information

• Chemical Name: Pyridine, 4-broMo-2,6-bis(trifluoroMethyl)-
• CAS No.: 134914-92-4
• Molecular Formula: C7H2BrF6N
• Molecular Weight: 293.9918992
• Mol file: 134914-92-4.mol

Synonyms:Pyridine, 4-broMo-2,6-bis(trifluoroMethyl)-;4-BROMO-2,6-BIS(TRIFLUOROMETHYL)PYRIDINE

Chemical Property of Pyridine, 4-broMo-2,6-bis(trifluoroMethyl)-

Chemical Property:

• Boiling Point: 139.7±35.0 °C(Predicted)
• PKA: -5.82±0.10(Predicted)
• PSA: 12.89000
• Density: 1.772±0.06 g/cm3(Predicted)
• LogP: 3.88170

Purity/Quality:

97% ^*data from raw suppliers

4-Bromo-2,6-bis-trifluoromethyl-pyridine 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Pyridine, 4-broMo-2,6-bis(trifluoroMethyl)-

There total 2 articles about Pyridine, 4-broMo-2,6-bis(trifluoroMethyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

2,6-bis(trifluoromethyl)-4-hydroxypyridine (43150-55-6) → 4-bromo-2,6-bis(trifluoromethyl)pyridine (134914-92-4)

Guidance literature:

With phosphorus tribromide; for 3h; Reflux;

DOI:10.1002/anie.201104588

Reference yield:

2,6-bis(trifluoromethyl)-2,6-dihydroxytetrahydropyran-4-one (425639-29-8) → 4-bromo-2,6-bis(trifluoromethyl)pyridine (134914-92-4)

Guidance literature:

Multi-step reaction with 2 steps

1: ammonia / water / 2 h / 140 °C

2: phosphorus tribromide / 3 h / Reflux

With ammonia; phosphorus tribromide; In water;

DOI:10.1002/anie.201104588

Reference yield: 52.0%

4-bromo-2,6-bis(trifluoromethyl)pyridine (134914-92-4) + (R)-[6,6′-dimethoxy(1,1′-biphenyl)-2,2′-diyl]phosphonous dichloride → (R)-(6,6′-dimethoxybiphenyl-2,2′-diyl)bis[bis[2,6-bis(trifluoromethyl)-pyridyl]phosphine]

Guidance literature:

4-bromo-2,6-bis(trifluoromethyl)pyridine; With diisobutylaluminium hydride; magnesium; lithium chloride; In diethyl ether; hexane; for 1h;

(R)-[6,6′-dimethoxy(1,1′-biphenyl)-2,2′-diyl]phosphonous dichloride; In tetrahydrofuran; diethyl ether; hexane; for 4h; Reflux;

upstream raw materials:

2,6-bis(trifluoromethyl)-2,6-dihydroxytetrahydropyran-4-one

2,6-bis(trifluoromethyl)-4-hydroxypyridine