ethyl 5-chloro-7-fluoro-1H-indole-2-carboxylate

Base Information

• Chemical Name: ethyl 5-chloro-7-fluoro-1H-indole-2-carboxylate
• CAS No.: 1204501-37-0
• Molecular Formula: C11H9ClFNO2
• Molecular Weight: 241.65
• Hs Code.: 2933998090
• Mol file: 1204501-37-0.mol

Synonyms:ethyl 5-chloro-7-fluoroindole-2-carboxylate;ethyl 5-chloro-7-fluoro-1H-indole-2-carboxylate;

Chemical Property of ethyl 5-chloro-7-fluoro-1H-indole-2-carboxylate

Chemical Property:

• Melting Point: 178-179 °C(Solv: hexane (110-54-3))
• Boiling Point: 372.6±37.0 °C(Predicted)
• PKA: 12.65±0.30(Predicted)
• PSA: 42.09000
• Density: 1.401±0.06 g/cm3(Predicted)
• LogP: 3.13710

Purity/Quality:

NLT 98% ^*data from raw suppliers

Ethyl5-Chloro-7-fluoro-1H-indole-2-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 5-chloro-7-fluoro-1H-indole-2-carboxylate

There total 2 articles about ethyl 5-chloro-7-fluoro-1H-indole-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 23.0%

ethyl 2-[(4-chloro-2-fluorophenyl)hydrazono]propanoate (1204501-36-9) → ethyl 5-chloro-7-fluoro-1H-indole-2-carboxylate (1204501-37-0)

Guidance literature:

With polyphosphoric acid; at 100 ℃; for 2h;

DOI:10.1016/j.bmc.2009.10.023

Reference yield:

2-oxo-propionic acid ethyl ester (617-35-6) + 2-fluoro-4-chloro-phenyl-hydrazine (64548-20-5) → ethyl 5-chloro-7-fluoro-1H-indole-2-carboxylate (1204501-37-0)

Guidance literature:

2-oxo-propionic acid ethyl ester; 2-fluoro-4-chloro-phenyl-hydrazine; With toluene-4-sulfonic acid; In toluene; for 14h; Reflux;

With sodium hydrogencarbonate; In water; ethyl acetate; toluene; at 20 ℃; Saturated solution;

DOI:10.1016/j.ejmech.2012.06.016

Reference yield: 100.0%

ethyl 5-chloro-7-fluoro-1H-indole-2-carboxylate (1204501-37-0) → 5-chloro-7-fluoro-1H-indole-2-carboxylic acid (383132-37-4)

Guidance literature:

(5-chloro-7-fluoro-1H-indol-2-yl)-carboxylic acid ethyl ester; With water; lithium hydroxide; In tetrahydrofuran; at 20 ℃;

With hydrogenchloride; In tetrahydrofuran; water;

DOI:10.1016/j.bmc.2009.10.023

upstream raw materials:

ethyl 2-[(4-chloro-2-fluorophenyl)hydrazono]propanoate

2-oxo-propionic acid ethyl ester

2-fluoro-4-chloro-phenyl-hydrazine

Downstream raw materials:

5-chloro-7-fluoro-1H-indole-2-carboxylic acid

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