6-Methyl-2-(oxiran-2-yl)-1,3,6,2-dioxazaborocane-4,8-dione

Base Information

• Chemical Name: 6-Methyl-2-(oxiran-2-yl)-1,3,6,2-dioxazaborocane-4,8-dione
• CAS No.: 1152427-91-2
• Molecular Formula: C₇H₁₀BNO₅
• Molecular Weight: 198.971
• Hs Code.: 2934999090
• Mol file: 1152427-91-2.mol

Synonyms:6-Methyl-2-(oxiran-2-yl)-1,3,6,2-dioxazaborocane-4,8-dione;Oxiranyl boronic acid MIDA ester;Oxiranyl boronic acid MIDA ester 95%

Chemical Property of 6-Methyl-2-(oxiran-2-yl)-1,3,6,2-dioxazaborocane-4,8-dione

Chemical Property:

• Melting Point: 188-193℃
• PSA: 68.37000
• LogP: -1.19780
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

Oxiranyl boronic acid MIDA ester 95% ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Suzuki Cross-Coupling with MIDA Boronates

Technology Process of 6-Methyl-2-(oxiran-2-yl)-1,3,6,2-dioxazaborocane-4,8-dione

There total 1 articles about 6-Methyl-2-(oxiran-2-yl)-1,3,6,2-dioxazaborocane-4,8-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

6-methyl-2-vinyl-1,3,6,2-dioxazaborocane-4,8-dione (1104636-73-8) → 2-N-methyliminodiacetic acid boryl oxirane (1152427-91-2)

Guidance literature:

With 3-chloro-benzenecarboperoxoic acid; In acetonitrile; at 35 ℃; for 26h; under 760.051 Torr;

DOI:10.15227/orgsyn.097.0157

Reference yield:

2-N-methyliminodiacetic acid boryl oxirane (1152427-91-2) → 2-(8-(benzyloxy)imidazo[1,2-a]pyridin-2-yl)-6-methyl-1,3,6,2-dioxazaborocane-4,8-dione

Guidance literature:

Multi-step reaction with 3 steps

1.1: lithium bromide; acetic acid / acetonitrile / 3 h / 20 °C

2.1: Dess-Martin periodane / acetonitrile / 1 h / 20 °C

3.1: acetonitrile / 24 h / 70 °C

3.2: 70 °C

With Dess-Martin periodane; acetic acid; lithium bromide; In acetonitrile;

DOI:10.1021/acs.orglett.5b02741

upstream raw materials:

6-methyl-2-vinyl-1,3,6,2-dioxazaborocane-4,8-dione