2-(4-BROMOBENZOYL)OXAZOLE

Base Information

• Chemical Name: 2-(4-BROMOBENZOYL)OXAZOLE
• CAS No.: 698355-80-5
• Molecular Formula: C10H6BrNO2
• Molecular Weight: 252.067
• Hs Code.: 2934999090
• Mol file: 698355-80-5.mol

Synonyms:2-(4-BROMOBENZOYL)OXAZOLE

Chemical Property of 2-(4-BROMOBENZOYL)OXAZOLE

Chemical Property:

• Vapor Pressure: 1.6E-05mmHg at 25°C
• Boiling Point: 365.1°C at 760 mmHg
• Flash Point: 174.6°C
• PSA: 43.10000
• Density: 1.577g/cm³
• LogP: 2.66810

Purity/Quality:

95% ^*data from raw suppliers

2-(4-Bromobenzoyl)oxazole 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(4-BROMOBENZOYL)OXAZOLE

There total 1 articles about 2-(4-BROMOBENZOYL)OXAZOLE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

(4-bromophenyl)-oxazol-2-yl-methanol (698355-75-8) → (4-bromophenyl)-oxazol-2-yl-methanone (698355-80-5)

Guidance literature:

With pyridinium chlorochromate; In dichloromethane; at 20 ℃; for 0.5h;

Reference yield: 88.0%

(4-bromophenyl)-oxazol-2-yl-methanone (698355-80-5) + 5-isobutyl-2 -(tert-butylaminosulfonyl)-3-thiopheneboronic acid (163520-14-7) → 3-[4-(oxazole-2-carbonyl)-phenyl]-5-isobutyl-N-tert-butylthiophene-2-sulfonamide (698355-86-1)

Guidance literature:

With sodium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In ethanol; water; toluene; at 100 ℃; for 3h;

Reference yield: 88.0%

(4-bromophenyl)-oxazol-2-yl-methanone (698355-80-5) + C18H26BNO4S2 → 3-[4-(oxazole-2-carbonyl)-phenyl]-5-isobutyl-N-tert-butylthiophene-2-sulfonamide (698355-86-1)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydroxide; In ethanol; toluene; at 100 ℃; for 3h; Inert atmosphere;

DOI:10.1016/j.bmc.2010.03.064

upstream raw materials:

(4-bromophenyl)-oxazol-2-yl-methanol

Downstream raw materials:

3-[4-(oxazole-2-carbonyl)-phenyl]-5-isobutyl-N-tert-butylthiophene-2-sulfonamide

Refernces

• 1、 -. "NEW TRICYCLIC ANGIOTENSIN II AGONISTS". Page 51-52. . Retrieved 2010/02/07.