5-Methoxy-2,3-pyridinediamine Dihydrochloride

Base Information

• Chemical Name: 5-Methoxy-2,3-pyridinediamine Dihydrochloride
• CAS No.: 127356-15-4
• Molecular Formula: C₆H₉N₃O*2ClH
• Molecular Weight: 212.079
• Mol file: 127356-15-4.mol

Synonyms:5-Methoxy-2,3-pyridinediamine Dihydrochloride

Chemical Property of 5-Methoxy-2,3-pyridinediamine Dihydrochloride

Chemical Property:

• PSA: 74.16000
• LogP: 3.02100

Purity/Quality:

97% ^*data from raw suppliers

5-Methoxy-2,3-pyridinediamineDihydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: An intermediate of Sulmazole and Isomazole analogs An intermediate of Sulmazole and Isomazole analogs.

Technology Process of 5-Methoxy-2,3-pyridinediamine Dihydrochloride

There total 1 articles about 5-Methoxy-2,3-pyridinediamine Dihydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

2,3-diamino-5-methoxy-6-(methylthio)pyridine hydrochloride (127356-35-8) → 2,3-diamino-5-methoxypyridine dihydrochloride (127356-15-4)

Guidance literature:

nickel; In water; at 100 ℃;

DOI:10.1021/jm00170a030

Reference yield: 30.0%

2-methoxy-4-(methylsulfanyl)benzoic acid (72856-73-6) + 2,3-diamino-5-methoxypyridine dihydrochloride (127356-15-4) → 6-methoxy-2-<2-methoxy-4-(methylthio)phenyl>-1H-imidazo<4,5-b>pyridine (127356-19-8)

Guidance literature:

With trichlorophosphate; 1.) RT, 0.5 h, 2.) reflux, 6 h;

DOI:10.1021/jm00170a030

Reference yield:

2,3-diamino-5-methoxypyridine dihydrochloride (127356-15-4) → 2-(4-Methanesulfinyl-2-methoxy-phenyl)-6-methoxy-1H-imidazo[4,5-b]pyridine (127356-02-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 30 percent / POCl₃ / 1.) RT, 0.5 h, 2.) reflux, 6 h

2: 62 percent / H₂O₂, acetic acid / 6 h / Ambient temperature

With dihydrogen peroxide; acetic acid; trichlorophosphate;

DOI:10.1021/jm00170a030

upstream raw materials:

2,3-diamino-5-methoxy-6-(methylthio)pyridine hydrochloride

Downstream raw materials:

6-methoxy-2-<2-methoxy-4-(methylthio)phenyl>-1H-imidazo<4,5-b>pyridine

2-(4-Methanesulfinyl-2-methoxy-phenyl)-6-methoxy-1H-imidazo[4,5-b]pyridine

Refernces