(4-Amino-3-hydroxyphenyl)sulfur pentafluoride

Base Information

• Chemical Name: (4-Amino-3-hydroxyphenyl)sulfur pentafluoride
• CAS No.: 1159512-48-7
• Molecular Formula: C6H6F5NOS
• Molecular Weight: 235.178
• Hs Code.: 2812900090
• Mol file: 1159512-48-7.mol

Synonyms:(4-Amino-3-hydroxyphenyl)sulfur pentafluoride;2-Amino-5-(pentafluorosulfanyl)phenol

Chemical Property of (4-Amino-3-hydroxyphenyl)sulfur pentafluoride

Chemical Property:

• Melting Point: 142-143 °C(Solv: chloroform (67-66-3))
• PKA: 8.35±0.10(Predicted)
• PSA: 71.55000
• LogP: 4.21300
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

4-Amino-3-hydroxyphenylsulfur pentafluoride ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (4-Amino-3-hydroxyphenyl)sulfur pentafluoride

There total 2 articles about (4-Amino-3-hydroxyphenyl)sulfur pentafluoride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

2-nitro-5-(pentafluorosulfanyl)phenol (1329120-21-9) → 4-amino-3-hydroxy(pentafluorosulfanyl)benzene (1159512-48-7)

Guidance literature:

With 10 wt% Pd(OH)2 on carbon; hydrogen; In ethanol; for 3h;

Reference yield:

1-nitro-4-(pentafluorosulfanyl)benzene (2613-27-6) → 4-amino-3-hydroxy(pentafluorosulfanyl)benzene (1159512-48-7)

Guidance literature:

Multi-step reaction with 2 steps

1: Cumene hydroperoxide; potassium tert-butylate; ammonia / tetrahydrofuran / 0.25 h / -50 °C

2: hydrogen / ethanol / 3 h / 20 °C

With Cumene hydroperoxide; potassium tert-butylate; ammonia; hydrogen; In tetrahydrofuran; ethanol;

DOI:10.1016/j.tetlet.2011.06.011

Reference yield: 65.0%

4-amino-3-hydroxy(pentafluorosulfanyl)benzene (1159512-48-7) + di(1H-imidazol-1-yl)methanimine (104619-51-4) → 6-(pentafluorosulfanyl)benzo[d]oxazol-2-amine

Guidance literature:

In acetonitrile; at 80 ℃; for 6h;

upstream raw materials:

2-nitro-5-(pentafluorosulfanyl)phenol

1-nitro-4-(pentafluorosulfanyl)benzene