ethyl 5-(4-fluorophenyl)-4-oxo-1,4-dihydropyridine-3-carboxylate

Base Information

• Chemical Name: ethyl 5-(4-fluorophenyl)-4-oxo-1,4-dihydropyridine-3-carboxylate
• CAS No.: 1052114-80-3
• Molecular Formula: C14H12FNO3
• Molecular Weight: 261.253
• Mol file: 1052114-80-3.mol

Synonyms:ethyl 5-(4-fluorophenyl)-4-oxo-1,4-dihydropyridine-3-carboxylate;ethyl 5-(4-fluorophenyl)-1,4-dihydro-4-oxopyridine-3-carboxylate

Chemical Property of ethyl 5-(4-fluorophenyl)-4-oxo-1,4-dihydropyridine-3-carboxylate

Chemical Property:

Purity/Quality:

98%min ^*data from raw suppliers

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SDS file from LookChem

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Technology Process of ethyl 5-(4-fluorophenyl)-4-oxo-1,4-dihydropyridine-3-carboxylate

There total 8 articles about ethyl 5-(4-fluorophenyl)-4-oxo-1,4-dihydropyridine-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

4-(4-fluorophenyl)-3-oxobutanoic acid ethyl ester (221121-37-5) → ethyl 5-(4-fluorophenyl)-4-oxo-1,4-dihydropyridine-3-carboxylate (1052114-80-3)

Guidance literature:

With sodium ethanolate; In ethanol; at 20 - 85 ℃;

Reference yield: 78.0%

1,3,5-Triazine (290-87-9) + 4-(4-fluorophenyl)-3-oxobutanoic acid ethyl ester (221121-37-5) → ethyl 5-(4-fluorophenyl)-4-oxo-1,4-dihydropyridine-3-carboxylate (1052114-80-3)

Guidance literature:

With sodium ethanolate; In ethanol; at 20 - 85 ℃; Inert atmosphere;

DOI:10.1021/jm800476q

Reference yield: 69.0%

N,N-dimethyl-formamide dimethyl acetal (4637-24-5) + 4-(4-fluorophenyl)-3-oxobutanoic acid ethyl ester (221121-37-5) → ethyl 5-(4-fluorophenyl)-4-oxo-1,4-dihydropyridine-3-carboxylate (1052114-80-3)

Guidance literature:

N,N-dimethyl-formamide dimethyl acetal; 4-(4-fluorophenyl)-3-oxobutanoic acid ethyl ester; In toluene; at 100 ℃; for 5h;

With ammonium acetate; In ethanol; at 60 ℃; for 5h;

DOI:10.1016/j.ejmech.2021.113497

upstream raw materials:

1,3,5-Triazine

4-(4-fluorophenyl)-3-oxobutanoic acid ethyl ester

N,N-dimethyl-formamide dimethyl acetal

4-Fluorophenylacetyl chloride

Downstream raw materials:

5-(4-fluorophenyl)-4-oxo-1,4-dihydropyridin-3-ylcarboxylic acid

ethyl 5-(4-fluorophenyl )-1-methyl-4-oxo-1,4-dihydropyridine-3-carboxylate

N-(4-(2-[bis[(1,1-dimethylethoxy)carbonyl]amino]-3-(1-methyl-1H-pyrazol-4-yl)pyridin-4-yloxy)-2,5-difluorophenyl)-5-(4-fluorophenyl)-1-methyl-4-oxo-1,4-dihydropyridine-3-carboxamide

N-(4-(2-amino-3-(1-methyl-1H-pyrazol-4-yl)pyridin-4-yloxy)-2,5-difluorophenyl)-5-(4-fluorophenyl)-1-methyl-4-oxo-1,4-dihydropyridine-3-carboxamide

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