H2N-PEG12-tBu

Base Information

• Chemical Name: H2N-PEG12-tBu
• CAS No.: 1383814-00-3
• Molecular Formula: C₃₁H₆₃NO₁₄
• Molecular Weight: 673.84
• Mol file: 1383814-00-3.mol

Synonyms:H2N-PEG12-tBu

Chemical Property of H2N-PEG12-tBu

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

H2N-PEG12-CH2CH2COOtBu min.97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of H2N-PEG12-tBu

There total 4 articles about H2N-PEG12-tBu which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tert-butyl 1-(tosyloxy)-3,6,9,12,15,18,21,24,27,30,33,36-dodecaoxanonatriacontan-39-oate → tert-butyl 1-amino-3,6,9,12,15,18,21,24,27,30,33,36-dodecaoxanonatriacontan-39-oate (1383814-00-3)

Guidance literature:

With ammonium hydroxide; tetrabutyl-ammonium chloride; In dichloromethane; at 40 ℃; for 24h;

Reference yield:

dodecaethylene glycol (6790-09-6) → tert-butyl 1-amino-3,6,9,12,15,18,21,24,27,30,33,36-dodecaoxanonatriacontan-39-oate (1383814-00-3)

Guidance literature:

Multi-step reaction with 3 steps

1.1: sodium / 1,4-dioxane / 1 h / 20 °C

1.2: 12 h / 20 °C

2.1: sodium hydroxide / dichloromethane / 10 h / 40 °C

3.1: ammonium hydroxide; tetrabutyl-ammonium chloride / dichloromethane / 24 h / 40 °C

With ammonium hydroxide; tetrabutyl-ammonium chloride; sodium; sodium hydroxide; In 1,4-dioxane; dichloromethane;

Reference yield:

tert-butyl 39-hydroxy-4,7,10,13,16,19,22,25,28,31,34,37-dodecaoxanonatriacontanoate → tert-butyl 1-amino-3,6,9,12,15,18,21,24,27,30,33,36-dodecaoxanonatriacontan-39-oate (1383814-00-3)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydroxide / dichloromethane / 10 h / 40 °C

2: ammonium hydroxide; tetrabutyl-ammonium chloride / dichloromethane / 24 h / 40 °C

With ammonium hydroxide; tetrabutyl-ammonium chloride; sodium hydroxide; In dichloromethane;

upstream raw materials:

dodecaethylene glycol

tert-Butyl acrylate

Refernces