Sarsasapogenin 3-O-β-D-galactopyranosid

Base Information

• Chemical Name: Sarsasapogenin 3-O-β-D-galactopyranosid
• CAS No.: 68422-00-4
• Molecular Formula: C33H54O8
• Molecular Weight: 578.787

Synonyms:Sarsasapogenin 3-O-β-D-galactopyranosid;TiMosaponin A1

Chemical Property of Sarsasapogenin 3-O-β-D-galactopyranosid

Chemical Property:

• Boiling Point: 695.5±55.0 °C(Predicted)
• PKA: 12.91±0.70(Predicted)
• PSA: 117.84000
• Density: 1.26±0.1 g/cm3 (20 ºC 760 Torr)
• LogP: 3.61800

Purity/Quality:

99%, ^*data from raw suppliers

Timosaponin A1 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Timosaponin A1 exhibits a wide spectrum of bioactivities. Also, it is a metabolite of Timosaponin A3 (T444695), which suppresses certain human tumor processes and has the potential to be developed as an anticancer agent. Reverses multi-drug resistance in human chronic myelogenous leukemia K562/ADM cells via downregulation of MDR1 and MRP1 expression by inhibiting PI3K/Akt signaling pathway. Induction of mitochondrial-dependent apoptosis in HepG2 human hepatocellular carcinoma cells.Timosaponin A3 is a potent inhibitor of U46619, that induces rat platelet aggregation and exhibited superior selectivity for the TP receptor vs. other G protein-coupled receptors and a PKC activator.

Technology Process of Sarsasapogenin 3-O-β-D-galactopyranosid

There total 14 articles about Sarsasapogenin 3-O-β-D-galactopyranosid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

sarsasapogenin 3,6-di-O-benzoyl-β-D-glucopyranose (1186633-13-5) → sarsasapogenin-3-O-β-galactopyranoside (68422-00-4)

Guidance literature:

With methanol; sodium methylate; In dichloromethane; at 20 ℃; for 3.5h;

Reference yield:

anemarrhenasaponin IV (142759-74-8,139051-27-7) → sarsasapogenin-3-O-β-galactopyranoside (68422-00-4) + timosaponin B III-b (1365029-75-9) + 3β-hydroxy-5β-pregn-16(17)-ene-20-one (566-59-6) + timopregnane A + 3-O-β-D-galactopyranosyl-(3β,5β)-pregn-16(17)-ene-20-one + timosaponin B III-d + (25S)-5β-spirostan-3β-ol-3-O-β-D-glucopyranosyl-(1->2)-β-D-galactopyranoside + sarsasapogenin (126-19-2)

Guidance literature:

With nitric acid; In water; at 100 ℃; for 3h;

DOI:10.1080/14786419.2018.1499640

Reference yield:

→ O-β-D-Glucopyranosyl-tigogenin (14835-43-9,29685-52-7,31217-07-9,35068-81-6,35959-24-1,63163-00-8,68422-00-4,70954-49-3,75657-39-5)

Guidance literature:

With acetic acid; platinum; Hydrogenation;

DOI:10.1021/ja01866a078

upstream raw materials:

C₄₁H₆₂O₁₂

melongoside E

C₅₃H₇₈O₂₀

isopropyl β-D-thiogalactopyranoside

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