2-amino-4-fluoronaphthalene

Base Information

• Chemical Name: 2-amino-4-fluoronaphthalene
• CAS No.: 13720-48-4
• Molecular Formula: C₁₀H₈FN
• Molecular Weight: 161.179
• Mol file: 13720-48-4.mol

Synonyms:2-amino-4-fluoronaphthalene;4-Fluoronaphthalen-2-amine

Chemical Property of 2-amino-4-fluoronaphthalene

Chemical Property:

• Melting Point: 80 °C
• Boiling Point: 314.0±15.0 °C(Predicted)
• PKA: 3.35±0.10(Predicted)
• PSA: 26.02000
• Density: 1.239±0.06 g/cm3(Predicted)
• LogP: 3.14230

Purity/Quality:

99% ^*data from raw suppliers

2-Amino-4-fluoronaphthalene ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-amino-4-fluoronaphthalene

There total 4 articles about 2-amino-4-fluoronaphthalene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-Fluoro-3-nitronaphthalin (394-93-4) → 3-Amino-1-fluor-naphthalin (13720-48-4)

Guidance literature:

With iron; iron(II) sulfate;

Reference yield:

4-Fluoro-2-nitro-1-naphthylamine (51670-65-6) → 3-Amino-1-fluor-naphthalin (13720-48-4)

Guidance literature:

Multi-step reaction with 2 steps

1: (i) NaNO₂, H₂SO₄, AcOH, (ii) Cu₂O, EtOH

2: H₂ / Pd-C / ethanol

With hydrogen; palladium on activated charcoal; In ethanol;

DOI:10.1021/ja00978a038

Reference yield:

4-Fluor-2-nitro-1-acetamino-naphthalin (13917-00-5) → 3-Amino-1-fluor-naphthalin (13720-48-4)

Guidance literature:

Multi-step reaction with 3 steps

1: HCl / ethanol

2: (i) NaNO₂, H₂SO₄, AcOH, (ii) Cu₂O, EtOH

3: H₂ / Pd-C / ethanol

With hydrogenchloride; hydrogen; palladium on activated charcoal; In ethanol;

DOI:10.1021/ja00978a038

upstream raw materials:

1-Fluoro-3-nitronaphthalin

3-nitro-1-naphthalenamine

4-Fluoro-2-nitro-1-naphthylamine

4-Fluor-2-nitro-1-acetamino-naphthalin