7-bromo-1H-benzo[d][1,3]oxazin-2(4H)-one

Base Information

• Chemical Name: 7-bromo-1H-benzo[d][1,3]oxazin-2(4H)-one
• CAS No.: 1245808-46-1
• Molecular Formula: C₈H₆BrNO₂
• Molecular Weight: 228.045
• Hs Code.: 2934999090
• Mol file: 1245808-46-1.mol

Synonyms:7-bromo-1H-benzo[d][1,3]oxazin-2(4H)-one;7-Bromo-1,4-dihydro-2H-3,1-benzoxazin-2-one

Chemical Property of 7-bromo-1H-benzo[d][1,3]oxazin-2(4H)-one

Chemical Property:

• PSA: 41.82000
• Density: 1.676
• LogP: 1.96040

Purity/Quality:

97% ^*data from raw suppliers

7-Bromo-1H-benzo[d][1,3]oxazin-2(4H)-one ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 7-bromo-1H-benzo[d][1,3]oxazin-2(4H)-one

There total 4 articles about 7-bromo-1H-benzo[d][1,3]oxazin-2(4H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 20.0%

3-bromobenzyl azidoformate → 5-bromo-2,4-dihydro-1H-3,1-benzoxazin-2-one (861106-93-6) + 7-bromo-1,4-dihydro-2H-benzo[d][1,3]oxazin-2-one (1245808-46-1)

Guidance literature:

With C₁₉H₁₉Cl₃CoNO; sodium tetrakis[(3,5-di-trifluoromethyl)phenyl]borate; at 60 ℃; for 12h; Sealed tube;

DOI:10.1021/jacs.0c04448

Reference yield:

(3-Bromophenyl)methanol (15852-73-0) → 5-bromo-2,4-dihydro-1H-3,1-benzoxazin-2-one (861106-93-6) + 7-bromo-1,4-dihydro-2H-benzo[d][1,3]oxazin-2-one (1245808-46-1)

Guidance literature:

Multi-step reaction with 4 steps

1: tetrahydrofuran / 0.5 h / 20 °C

2: hydrazine hydrate / dichloromethane / 2 h / 20 °C

3: acetic acid; sodium nitrite / water; acetonitrile / 1.25 h / 0 - 20 °C

4: C₁₉H₁₉Cl₃CoNO; sodium tetrakis[(3,5-di-trifluoromethyl)phenyl]borate / 12 h / 60 °C / Sealed tube

With hydrazine hydrate; C₁₉H₁₉Cl₃CoNO; acetic acid; sodium tetrakis[(3,5-di-trifluoromethyl)phenyl]borate; sodium nitrite; In tetrahydrofuran; dichloromethane; water; acetonitrile;

DOI:10.1021/jacs.0c04448

Reference yield:

C11H9BrN2O2 → 5-bromo-2,4-dihydro-1H-3,1-benzoxazin-2-one (861106-93-6) + 7-bromo-1,4-dihydro-2H-benzo[d][1,3]oxazin-2-one (1245808-46-1)

Guidance literature:

Multi-step reaction with 3 steps

1: hydrazine hydrate / dichloromethane / 2 h / 20 °C

2: acetic acid; sodium nitrite / water; acetonitrile / 1.25 h / 0 - 20 °C

3: C₁₉H₁₉Cl₃CoNO; sodium tetrakis[(3,5-di-trifluoromethyl)phenyl]borate / 12 h / 60 °C / Sealed tube

With hydrazine hydrate; C₁₉H₁₉Cl₃CoNO; acetic acid; sodium tetrakis[(3,5-di-trifluoromethyl)phenyl]borate; sodium nitrite; In dichloromethane; water; acetonitrile;

DOI:10.1021/jacs.0c04448

upstream raw materials:

(3-Bromophenyl)methanol

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 1245808-46-1 7-bromo-1H-benzo[d][1,3]oxazin-2(4H)-one

Send

Send

Metric Ton KG G Pound L ML

Send

Send