5-broMo-4-chloro-2-(Methylthio)-7H-Pyrrolo[2,3-d]pyriMidine

Base Information

• Chemical Name: 5-broMo-4-chloro-2-(Methylthio)-7H-Pyrrolo[2,3-d]pyriMidine
• CAS No.: 183274-54-6
• Molecular Formula: C₇H₅BrClN₃S
• Molecular Weight: 278.56
• Mol file: 183274-54-6.mol

Synonyms:5-broMo-4-chloro-2-(Methylthio)-7H-Pyrrolo[2,3-d]pyriMidine

Chemical Property of 5-broMo-4-chloro-2-(Methylthio)-7H-Pyrrolo[2,3-d]pyriMidine

Chemical Property:

• Boiling Point: 284.5±50.0 °C(Predicted)
• PKA: 8.05±0.20(Predicted)
• PSA: 66.87000
• Density: 2.02±0.1 g/cm3(Predicted)
• LogP: 3.09570

Purity/Quality:

98%Min ^*data from raw suppliers

5-BROMO-4-CHLORO-2-(METHYLTHIO)-7H-PYRROLO-[2,3-D]-PYRIMIDINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-broMo-4-chloro-2-(Methylthio)-7H-Pyrrolo[2,3-d]pyriMidine

There total 1 articles about 5-broMo-4-chloro-2-(Methylthio)-7H-Pyrrolo[2,3-d]pyriMidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

2-(methylthio)-4-chloropyrrolo<2,3-d>pyrimidine (57564-94-0) → 5-bromo-4-chloro-2-(methylthio)-7H-pyrrolo<2,3-d>pyrimidine (183274-54-6)

Guidance literature:

With N-Bromosuccinimide; In N,N-dimethyl-formamide; for 18h; Ambient temperature;

DOI:10.1002/(SICI)1522-2675(19990113)82:1<12::AID-HLCA12>3.0.CO;2-L

Reference yield:

2-deoxy-3,5-di-O-p-toluoyl-α-D-erythro-pentofuranosyl chloride (4330-21-6) + 5-bromo-4-chloro-2-(methylthio)-7H-pyrrolo<2,3-d>pyrimidine (183274-54-6) → C28H25BrClN3O5S

Guidance literature:

With potassium hydroxide; Tris(3,6-dioxaheptyl)amine; In acetonitrile; for 0.25h; Ambient temperature;

DOI:10.1002/(SICI)1522-2675(19990113)82:1<12::AID-HLCA12>3.0.CO;2-L

upstream raw materials:

2-(methylthio)-4-chloropyrrolo<2,3-d>pyrimidine