(R)-b-(Boc-amino)-2,5-difluorobenzenebutanoic acid

Base Information

Chemical Name:(R)-b-(Boc-amino)-2,5-difluorobenzenebutanoic acid
CAS No.:486459-98-7
Molecular Formula:C15H19F2NO4
Molecular Weight:315.317
Hs Code.:
UNII:GZ7Y2A878J
Nikkaji Number:J2.163.907I
Mol file:486459-98-7.mol

Synonyms:486459-98-7;(R)-b-(Boc-amino)-2,5-difluorobenzenebutanoic acid;Sitagliptin Defuoro IMpurity 4;(3R)-3-[(1,1-Dimethylethoxycarbonyl)amino]-4-(2,5-difluorophenyl)butanoic Acid;(3R)-3-[(tert-Butoxycarbonyl)amino]-4-(2,5-difluorophenyl)butanoic acid;(R)-3-[((tert-Butoxy)carbonyl)amino]-4-(2,5-difluorophenyl)butanoic Acid;GZ7Y2A878J;SCHEMBL1509219;DYAISPAQPPRCQC-LLVKDONJSA-N;MFCD09029663;AKOS015962698;(3R)-4-(2,5-difluorophenyl)-3-[(2-methylpropan-2-yl)oxycarbonylamino]butanoic Acid;BS-17102;CS-0165424;D80588;A899716;(R)-b-(Boc-amino)-2,5-difluorobenzenebutanoicacid;(R)-beta-(Boc-amino)-2,5-difluorobenzenebutanoic acid;3-[(tert-Butoxycarbonyl)amino]-4-(2,5-difluorophenyl)butanoic acid, (3R)-;(3R)-3-[(1,1-dimethylethoxycarbonyl)amino]4-(2,5-difluorophenyl)butanoic acid;(betaR)-beta-[[(1,1-Dimethylethoxy)carbonyl]amino]-2,5-difluorobenzenebutanoic acid;Benzenebutanoic acid, beta-[[(1,1-dimethylethoxy)carbonyl]amino]-2,5-difluoro-, (betaR)-;(R)-3-((tert-butoxycarbonyl)amino)-4-(2,5-difluorophenyl)butanoic acid? (Sitagliptin Impurity pound(c)

Suppliers and Price of (R)-b-(Boc-amino)-2,5-difluorobenzenebutanoic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Biosynth Carbosynth
(R)-3-[((tert-Butoxy)carbonyl)amino]-4-(2,5-difluorophenyl)butanoic acid
50 mg
$ 275.00

Biosynth Carbosynth
(R)-3-[((tert-Butoxy)carbonyl)amino]-4-(2,5-difluorophenyl)butanoic acid
25 mg
$ 180.00

Biosynth Carbosynth
(R)-3-[((tert-Butoxy)carbonyl)amino]-4-(2,5-difluorophenyl)butanoic acid
100 mg
$ 420.00

Biosynth Carbosynth
(R)-3-[((tert-Butoxy)carbonyl)amino]-4-(2,5-difluorophenyl)butanoic acid
500 mg
$ 1000.00

Biosynth Carbosynth
(R)-3-[((tert-Butoxy)carbonyl)amino]-4-(2,5-difluorophenyl)butanoic acid
250 mg
$ 812.50

AK Scientific
(R)-b-(Boc-amino)-2,5-difluorobenzenebutanoicacid
100mg
$ 455.00

Acrotein
(R)-b-(Boc-amino)-2,5-difluorobenzenebutanoicacid 97%
0.5g
$ 366.67

ACHEMBLOCK
(R)-b-(Boc-amino)-2,5-difluorobenzenebutanoicacid 95%
250MG
$ 340.00

Total 14 raw suppliers

Chemical Property of (R)-b-(Boc-amino)-2,5-difluorobenzenebutanoic acid

Chemical Property:

Boiling Point:442.9±45.0 °C(Predicted)
PKA:4.35±0.10(Predicted)
PSA：75.63000
Density:1.243±0.06 g/cm3(Predicted)
LogP:3.26620
Storage Temp.:2-8°C
XLogP3:2.6
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:7
Exact Mass:315.12821441
Heavy Atom Count:22
Complexity:398

Purity/Quality:

97% ^*data from raw suppliers

(R)-3-[((tert-Butoxy)carbonyl)amino]-4-(2,5-difluorophenyl)butanoic acid ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C)(C)OC(=O)NC(CC1=C(C=CC(=C1)F)F)CC(=O)O
Isomeric SMILES:CC(C)(C)OC(=O)N[C@H](CC1=C(C=CC(=C1)F)F)CC(=O)O

Technology Process of (R)-b-(Boc-amino)-2,5-difluorobenzenebutanoic acid

There total 20 articles about (R)-b-(Boc-amino)-2,5-difluorobenzenebutanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 486460-03-1
(R,S)-3-[(1,1-dimethylethoxycarbonyl)amino]-1-diazo-4-(2,5-difluoro-phenyl)butan-2-one

: 486459-98-7
(3R)-3-[(1,1-dimethylethoxycarbonyl)amino]-4-(2,5-difluorophenyl)butanoic acid

Guidance literature:: (R,S)-3-[(1,1-dimethylethoxycarbonyl)amino]-1-diazo-4-(2,5-difluoro-phenyl)butan-2-one; With silver benzoate; N-ethyl-N,N-diisopropylamine; In methanol; at -30 ℃; for 1.5h;

With lithium hydroxide; In tetrahydrofuran; methanol; water; at 50 ℃; for 4h;