ACT 080803

Base Information

Chemical Name:ACT 080803
CAS No.:1433875-21-8
Molecular Formula:C₁₆H₁₃Br₂N₅O₂
Molecular Weight:467.12
Hs Code.:
Mol file:1433875-21-8.mol

Synonyms:ACT 080803;5-(4-Bromo-phenyl)-6-[2-(5-bromo-pyrimidin-2-yloxy)-ethoxy]-pyrimidin-4-ylamine

Suppliers and Price of ACT 080803

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
DespropylaminosulfonylMacitentan
5mg
$ 315.00

Chemenu
5-(4-bromophenyl)-6-[2-(5-bromopyrimidin-2-yl)oxyethoxy]pyrimidin-4-amine 95%+
1g
$ 4375.00

Arctom
5-(4-Bromophenyl)-6-(2-((5-bromopyrimidin-2-yl)oxy)ethoxy)pyrimidin-4-amine ≥98%
1g
$ 1024.00

Total 9 raw suppliers

Chemical Property of ACT 080803

Chemical Property:

PSA：96.04000
LogP:4.07980

Purity/Quality:

97% ^*data from raw suppliers

DespropylaminosulfonylMacitentan ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Uses Despropylaminosulfonyl Macitentan is an impurity of Macitentan (M105005); a dual orally active endothelin receptor antagonist used for pulmonary arterial hypertension.

Technology Process of ACT 080803

There total 9 articles about ACT 080803 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.16%

: macitentan

: 1433875-21-8
ACT-080803

Guidance literature:: With hydrogenchloride; In water; at 25 - 30 ℃;
DOI:10.1007/s00706-017-2098-2

Reference yield:

: macitentan

: 1433875-21-8
ACT-080803

: 2211059-05-9
2‐((6‐amino‐5‐(4‐bromophenyl)pyrimidin‐4‐yl)oxy)ethan‐1‐ol

: 6‐amino‐5‐(4‐bromophenyl)pyrimidin‐4‐ol

: 5‐bromo‐2‐(2‐chloroethoxy)pyrimidine

: 5‐(4‐bromophenyl)‐6‐(vinyloxy)pyrimidin‐4‐amine

: N‐[5‐(4‐bromophenyl)‐6‐hydroxy‐4‐pyrimidinyl]‐N′‐propylsulfamide

: 5‐(4‐bromophenyl)‐6‐(2‐chloroethoxy)pyrimidin‐4‐amine

: N-[5-(4-bromophenyl)-6-[2-chloroethoxy]-4-pyrimidinyl]-N'-propylsulfamide

: 38353-06-9,214290-49-0
5-bromopyrimidin-2-ol

Guidance literature:: With hydrogenchloride; In water; at 80 ℃; for 4h;
DOI:10.1002/rcm.8138

Reference yield:

: 1878-68-8
2-(4-bromophenyl)-acetic acid

: 1433875-21-8
ACT-080803

Guidance literature:: Multi-step reaction with 8 steps

1.1: sulfuric acid / 70 °C

2.1: sodium methylate / tetrahydrofuran / 1 h / 0 - 5 °C

2.2: 0 - 30 °C

3.1: sodium methylate / methanol / 70 °C

4.1: trichlorophosphate / 90 °C

5.1: lithium amide / dimethyl sulfoxide / 2 h / 20 - 25 °C

6.1: lithium amide / 18 h / 100 - 105 °C / Green chemistry

7.1: lithium tert-butoxide / tetrahydrofuran; N,N-dimethyl-formamide / 25 - 45 °C

8.1: hydrogenchloride / water / 25 - 30 °C

With hydrogenchloride; lithium amide; sulfuric acid; sodium methylate; lithium tert-butoxide; trichlorophosphate; In tetrahydrofuran; methanol; water; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1007/s00706-017-2098-2