Patulin

Base Information

• Chemical Name: Patulin
• CAS No.: 748133-69-9
• Molecular Formula: C₇H₆O₄
• Molecular Weight: 161.045
• Mol file: 748133-69-9.mol

Synonyms:Patulin-13C3

Chemical Property of Patulin

Chemical Property:

• PSA: 55.76000
• LogP: -0.29790

Purity/Quality:

NLT 98% ^*data from raw suppliers

Patulin-13C3 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Labelled Patulin (PAT), a mycotoxin produced by certain species of Penicillium, Aspergillus, and Byssochlamys, is mainly found in ripe apple and apple products. ation of glutathione in Hep G2 cells. Antibiotic.

Technology Process of Patulin

There total 7 articles about Patulin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

C5(13)C7H16O6 → patulin-13C7 (748133-69-9)

Guidance literature:

With 1,8-diazabicyclo[5.4.0]undec-7-ene; In dichloromethane; at 0 - 30 ℃; for 0.75h;

Reference yield:

C13(13)C7H30O5Si → patulin-13C7 (748133-69-9)

Guidance literature:

Multi-step reaction with 5 steps

1.1: pyridine; dmap / 24 h / 0 - 30 °C / Sealed tube

2.1: hydrogenchloride / methanol / 4 h / 20 - 30 °C

3.1: Dess-Martin periodane / dichloromethane / 4 h / 0 - 30 °C / Inert atmosphere

4.1: boron tribromide / dichloromethane / 0.5 h / -80 - -75 °C

4.2: 0.5 h / 20 - 30 °C

5.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 0.75 h / 0 - 30 °C

With pyridine; hydrogenchloride; dmap; boron tribromide; Dess-Martin periodane; 1,8-diazabicyclo[5.4.0]undec-7-ene; In methanol; dichloromethane;

Reference yield:

C18(13)C7H38O6Si → patulin-13C7 (748133-69-9)

Guidance literature:

Multi-step reaction with 4 steps

1.1: hydrogenchloride / methanol / 4 h / 20 - 30 °C

2.1: Dess-Martin periodane / dichloromethane / 4 h / 0 - 30 °C / Inert atmosphere

3.1: boron tribromide / dichloromethane / 0.5 h / -80 - -75 °C

3.2: 0.5 h / 20 - 30 °C

4.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 0.75 h / 0 - 30 °C

With hydrogenchloride; boron tribromide; Dess-Martin periodane; 1,8-diazabicyclo[5.4.0]undec-7-ene; In methanol; dichloromethane;

Refernces