4-(2-((Cyclohexylcarbamoyl)amino)ethyl)benzenesulfonamide

Base Information

• Chemical Name: 4-(2-((Cyclohexylcarbamoyl)amino)ethyl)benzenesulfonamide
• CAS No.: 10080-05-4
• Molecular Formula: C21H27N5O4S
• Molecular Weight: 325.432
• European Community (EC) Number: 642-316-7
• UNII: 160B179289
• DSSTox Substance ID: DTXSID40143521
• Nikkaji Number: J1.436.664D
• Wikidata: Q27251758
• ChEMBL ID: CHEMBL1368006
• Mol file: 10080-05-4.mol

Synonyms:10080-05-4;Glipizide EP Impurity H;4-(2-((Cyclohexylcarbamoyl)amino)ethyl)benzenesulfonamide;1-cyclohexyl-3-[2-(4-sulfamoylphenyl)ethyl]urea;UNII-160B179289;160B179289;4-(2-(3-Cyclohexylureido)ethyl)benzenesulfonamide;4-[2-[(Cyclohexylcarbamoyl)amino]ethyl]benzenesulphonamide;1-Cyclohexyl-3-(p-sulfamoylphenethyl)urea;4-{2-[(cyclohexylcarbamoyl)amino]ethyl}benzenesulfonamide;Glipizide Imp. H (EP);Glipizide Impurity H;CBMicro_015059;Cambridge id 6204432;Oprea1_627198;Oprea1_767535;MLS000777775;CHEMBL1368006;DTXSID40143521;HMS2744F15;4-[2-[[(Cyclohexylamino)carbonyl]amino]ethyl]benzenesulfonamide;STL357524;AKOS003660377;SMR000414096;BIM-0015111.P001;GLIPIZIDE IMPURITY H [EP IMPURITY];CS-0329913;FT-0665371;N-(4-aminosulfonylphenylethyl)-N'-cyclohexyl-urea;SR-01000230553;A1-05922;SR-01000230553-1;4-[2-(3-Cyclohexyl-ureido)-ethyl]-benzenesulfonamide;Q27251758;UREA, 1-CYCLOHEXYL-3-(P-SULFAMOYLPHENETHYL)-;Z56261634;BENZENESULFONAMIDE, 4-(2-(((CYCLOHEXYLAMINO)CARBONYL)AMINO)ETHYL)-

Chemical Property of 4-(2-((Cyclohexylcarbamoyl)amino)ethyl)benzenesulfonamide

Chemical Property:

• Melting Point: 200-202℃
• PSA: 113.16000
• LogP: 3.88480
• XLogP3: 1.7
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 5
• Exact Mass: 325.14601278
• Heavy Atom Count: 22
• Complexity: 447

Purity/Quality:

98%,99%, ^*data from raw suppliers

1-Cyclohexyl-3-(p-sulfamoylphenethyl)urea ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CCC(CC1)NC(=O)NCCC2=CC=C(C=C2)S(=O)(=O)N
• Uses: 1-Cyclohexyl-3-(p-sulfamoylphenethyl)urea is an impurity of Glipizide (G410225). 1-Cyclohexyl-3-(p-sulfamoylphenethyl)urea (Glipizide EP Impurity H) is an impurity of Glipizide (G410225).

Technology Process of 4-(2-((Cyclohexylcarbamoyl)amino)ethyl)benzenesulfonamide

There total 2 articles about 4-(2-((Cyclohexylcarbamoyl)amino)ethyl)benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

Cyclohexyl isocyanate (3173-53-3) + 4-(2-aminoethyl)benzenesulfonamide (35303-76-5) → 4-[2-(3-Cyclohexyl-ureido)-ethyl]-benzenesulfonamide (10080-05-4)

Guidance literature:

In N,N-dimethyl-formamide; at -4 - 20 ℃; for 2h; Solvent;

Reference yield:

→ 4-[2-(3-Cyclohexyl-ureido)-ethyl]-benzenesulfonamide (10080-05-4)

Guidance literature:

NH2-CH2-CH2-Ph-SO2-NH2, entspr. Isocyanat;

Reference yield:

4-[2-(3-Cyclohexyl-ureido)-ethyl]-benzenesulfonamide (10080-05-4) + Cyclohexyl isocyanate (3173-53-3) → C22H34N4O4S (10079-35-3)

Guidance literature:

4-[2-(3-Cyclohexyl-ureido)-ethyl]-benzenesulfonamide; With sodium hydroxide; In acetone; at 20 ℃; for 0.166667h;

Cyclohexyl isocyanate; In acetone; at 60 ℃; for 8h; Solvent; Reagent/catalyst;

upstream raw materials:

Cyclohexyl isocyanate

4-(2-aminoethyl)benzenesulfonamide

Downstream raw materials:

C₂₂H₃₄N₄O₄S