(2-bromo-3-fluorophenyl)methanol

Base Information

• Chemical Name: (2-bromo-3-fluorophenyl)methanol
• CAS No.: 1184915-45-4
• Molecular Formula: C₇H₆BrFO
• Molecular Weight: 205.026
• Hs Code.: 2906290090
• Mol file: 1184915-45-4.mol

Synonyms:(2-bromo-3-fluorophenyl)methanol;2-Bromo-3-fluorobenzenemethanol;2-Bromo-3-fluorobenzyl alcohol 97%;2-Bromo-3-fluorobenzylalcohol97%

Chemical Property of (2-bromo-3-fluorophenyl)methanol

Chemical Property:

• Boiling Point: 254℃
• Flash Point: 107℃
• PSA: 20.23000
• Density: 1.658
• LogP: 2.08050

Purity/Quality:

99%, ^*data from raw suppliers

2-Bromo-3-fluorobenzylAlcohol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (2-bromo-3-fluorophenyl)methanol

There total 2 articles about (2-bromo-3-fluorophenyl)methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

2-bromo-3-fluorobenzaldehyde (891180-59-9) → (2-bromo-3-fluorophenyl)methanol (1184915-45-4)

Guidance literature:

With sodium tetrahydroborate; In methanol; at 0 ℃; for 1h;

DOI:10.1021/acs.joc.8b01693

Reference yield:

2-bromo-3-fluoro-benzoic acid (132715-69-6) → (2-bromo-3-fluorophenyl)methanol (1184915-45-4)

Guidance literature:

With borane; pyridinium chlorochromate; In tetrahydrofuran; at 0 - 20 ℃; for 4h;

Reference yield:

(2-bromo-3-fluorophenyl)methanol (1184915-45-4) → ((1S,3R)-3-methyl-3H,3′H-1,1′-spirobi[isobenzofuran]-7,7′-diyl)-bis(diphenylphosphane)

Guidance literature:

Multi-step reaction with 5 steps

1.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 25 h / 0 - 20 °C / Inert atmosphere

2.1: n-butyllithium / tetrahydrofuran / 0.67 h / -78 °C / Inert atmosphere

2.2: 4.5 h / -70 - 0 °C

3.1: n-butyllithium / tetrahydrofuran / 1 h / -78 °C / Inert atmosphere

3.2: 5.5 h / -60 - 0 °C / Inert atmosphere

4.1: zinc dibromide / dichloromethane / 20 °C

5.1: zinc dibromide / tetrahydrofuran / 8 h / 85 °C / Sealed tube; Inert atmosphere

With n-butyllithium; N-ethyl-N,N-diisopropylamine; zinc dibromide; In tetrahydrofuran; dichloromethane;

DOI:10.1021/acs.joc.8b01693

upstream raw materials:

2-bromo-3-fluoro-benzoic acid

2-bromo-3-fluorobenzaldehyde

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