6-Chloro-4,5-dimethylpyridin-3-amine

Base Information

• Chemical Name: 6-Chloro-4,5-dimethylpyridin-3-amine
• CAS No.: 147440-83-3
• Molecular Formula: C₇H₉ClN₂
• Molecular Weight: 156.615
• Hs Code.: 2933399090
• DSSTox Substance ID: DTXSID50437120
• Wikidata: Q82252496
• Mol file: 147440-83-3.mol

Synonyms:6-Chloro-4,5-dimethylpyridin-3-amine;147440-83-3;5-Amino-2-chloro-3,4-dimethylpyridine;DTXSID50437120;AKOS016011780;SB55398;FT-0763568;EN300-137442

Chemical Property of 6-Chloro-4,5-dimethylpyridin-3-amine

Chemical Property:

• PSA: 38.91000
• LogP: 2.51520
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• XLogP3: 1.9
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 156.0454260
• Heavy Atom Count: 10
• Complexity: 118

Purity/Quality:

98%min ^*data from raw suppliers

6-Chloro-4,5-dimethylpyridin-3-amine 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=C(C(=NC=C1N)Cl)C

Technology Process of 6-Chloro-4,5-dimethylpyridin-3-amine

There total 2 articles about 6-Chloro-4,5-dimethylpyridin-3-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

2-chloro-3,4-dimethyl-5-nitropyridine (65169-35-9) → 5-amino-2-chloro-3,4-dimethylpyridine (147440-83-3)

Guidance literature:

With hydrogen; palladium on activated charcoal; In 1,4-dioxane; for 120h; under 3620.04 Torr; Ambient temperature;

DOI:10.1080/00397919308009790

Reference yield:

3,4-dimethyl-2-hydroxy-5-nitropyridine (65169-34-8) → 5-amino-2-chloro-3,4-dimethylpyridine (147440-83-3)

Guidance literature:

Multi-step reaction with 2 steps

1: POCl₃

2: 73 percent / H₂ / 5percent Pd/C / dioxane / 120 h / 3620.04 Torr / Ambient temperature

With hydrogen; trichlorophosphate; palladium on activated charcoal; In 1,4-dioxane;

DOI:10.1080/00397919308009790

Reference yield:

5-amino-2-chloro-3,4-dimethylpyridine (147440-83-3) → 5-methyl-3-phenyl-1,7-naphthyridine (147440-87-7)

Guidance literature:

Multi-step reaction with 4 steps

1: 89 percent / Et₃N / CH₂Cl₂ / a) 0 deg C, 15 min, b) RT, 2 h

2: 1.) n-BuLi / 1.) THF, hexane, 0 deg C, 3 h, 2.) THF, hexane, RT, 12 h

3: 60 percent / 2N aq. HCl / 5 h / Heating

4: 81.2 percent / H₂, 1N aq. NaOH / 5percent Pd/C / ethanol / 0.5 h / 2250.2 Torr

With hydrogenchloride; sodium hydroxide; n-butyllithium; hydrogen; triethylamine; palladium on activated charcoal; In ethanol; dichloromethane;

DOI:10.1080/00397919308009790

upstream raw materials:

2-chloro-3,4-dimethyl-5-nitropyridine

3,4-dimethyl-2-hydroxy-5-nitropyridine

Downstream raw materials:

5-methyl-3-phenyl-1,7-naphthyridine

3-phenyl-1,7-naphthyridine-5-carboxaldehyde

6-chloro-5-methyl-3-phenyl-1,7-naphthyridine

N-<2-chloro-4-(3,3-diethoxy-2-hydroxy-2-phenyl-propyl)-3-methylpyridin-5-yl>-2,2-dimethyl-propanamide

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