trapoxin A

Base Information

Chemical Name:trapoxin A
CAS No.:133155-89-2
Molecular Formula:C34H42 N4 O6
Molecular Weight:602.731
Hs Code.:
European Community (EC) Number:687-014-6
UNII:GSS8DX555X
DSSTox Substance ID:DTXSID20927982
Nikkaji Number:J359.332K
Wikidata:Q27157434
Metabolomics Workbench ID:98591
Mol file:133155-89-2.mol

Synonyms:cyclo((S)-phenylalanyl-(S)-phenylalanyl-(R)-pipecolinyl-(2S,9S)-2-amino-8-oxo-9,10-epoxydecanoyl);trapoxin;trapoxin A

Suppliers and Price of trapoxin A

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Sigma-Aldrich
Trapoxin A ≥98% (HPLC), from Helicoma ambiens
5mg
$ 581.00

Sigma-Aldrich
Trapoxin A ≥98% (HPLC), from Helicoma ambiens
1mg
$ 179.00

Cayman Chemical
Trapoxin A ≥98%
1mg
$ 155.00

Cayman Chemical
Trapoxin A ≥98%
5mg
$ 543.00

American Custom Chemicals Corporation
TRAPOXIN 95.00%
1MG
$ 707.64

American Custom Chemicals Corporation
TRAPOXIN 95.00%
5MG
$ 1122.48

AK Scientific
Trapoxin A
5mg
$ 804.00

AK Scientific
Trapoxin A
1mg
$ 301.00

Total 7 raw suppliers

Chemical Property of trapoxin A

Chemical Property:

Vapor Pressure:0mmHg at 25°C
Boiling Point:928.3°Cat760mmHg
Flash Point:515.2°C
PSA：137.21000
Density:1.27g/cm³
LogP:3.16360
Storage Temp.:?20°C
Solubility.:DMSO: soluble0.9-1.10 mg/ml, clear, colorless to faintly yellow
XLogP3:3.4
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:11
Exact Mass:602.31043507
Heavy Atom Count:44
Complexity:1020

Purity/Quality:

98%,99%, ^*data from raw suppliers

Trapoxin A ≥98% (HPLC), from Helicoma ambiens ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:T
Statements: 25
Safety Statements: 45

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Canonical SMILES:C1CCN2C(C1)C(=O)NC(C(=O)NC(C(=O)NC(C2=O)CC3=CC=CC=C3)CC4=CC=CC=C4)CCCCCC(=O)C5CO5
Isomeric SMILES:C1CCN2[C@H](C1)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C2=O)CC3=CC=CC=C3)CC4=CC=CC=C4)CCCCCC(=O)[C@@H]5CO5
Description Trapoxin A is a cyclotetrapeptide histone deacetylase (HDAC) inhibitor. It inhibits HDAC activity in a concentration-dependent and irreversible manner. Trapoxin A inhibits proliferation of NIH3T3 cells transformed by the oncogene v-sis (sis/NIH3T3; IC50 = ~200 ng/ml) and has detransformation activity, flattening sis/NIH3T3 cells when used at a concentration of 1 ng/ml. It also halts the cell cycle at the G2 phase in 3Y1 fibroblasts when used at a concentration of 10 nM and inhibits growth of TR303 cells resistant to trichostatin A at a concentration of 50 ng/ml.
Uses Trapoxin A has been used:to study its effects on the inhibition of histone deacetylase 11 (HDAC11)to study its effects on the inhibition of HDAC3 in human cell linesto study its effects on the inhibition of HDAC6 in rat pyramidal neurons

Technology Process of trapoxin A

There total 1 articles about trapoxin A which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%