Chemical Property of Sauchinone
Chemical Property:
- Melting Point:224-226℃
- Boiling Point:498.1±45.0 °C(Predicted)
- PSA：63.22000
- Density:1.43±0.1 g/cm3 (20 oC 760 Torr)
- LogP:2.96680
- Storage Temp.:2-8°C
- Solubility.:DMSO: soluble5mg/mL, clear (warmed)
- XLogP3:2.8
- Hydrogen Bond Donor Count:0
- Hydrogen Bond Acceptor Count:6
- Rotatable Bond Count:0
- Exact Mass:356.12598835
- Heavy Atom Count:26
- Complexity:675
- Purity/Quality:
-
95%-98% *data from raw suppliers
Sauchinone *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:
- Safety Statements:
24/25
- MSDS Files:
-
SDS file from LookChem
Useful:
- Canonical SMILES:CC1CC2C3C(C1C)C4=CC5=C(C=C4OC36C(=CC2=O)OCO6)OCO5
- Isomeric SMILES:C[C@@H]1C[C@@H]2[C@H]3[C@@H]([C@H]1C)C4=CC5=C(C=C4O[C@@]36C(=CC2=O)OCO6)OCO5
-
Uses
Sauchinone is a lignan first isolated from the aerial parts of S. chinensis, a plant used in Asian medicine for its anti-inflammatory, anti-angiogenic, and anti-nociceptive activities. Sauchinone has numerous effects on isolated cells, including blocking NF-κB activation in LPS-stimulated macrophages, inducing heme oxygenase-1 transcription in endothelial cells, and attenuating oxidative-stress-induced damage in myoblasts. Sauchinone is extensively metabolized in vivo, but intraperitoneal administration significantly reduces myocardial infarct size induced by ischemia/reperfusion in mice.
