Gallopamil, (-)-

Base Information

Chemical Name:Gallopamil, (-)-
CAS No.:36622-40-9
Molecular Formula:C₂₈H₄₀N₂O₅
Molecular Weight:484.636
Hs Code.:
UNII:5X7S7C93QM
Nikkaji Number:J441.677E
Wikidata:Q27263000
ChEMBL ID:CHEMBL1401296
Mol file:36622-40-9.mol

Synonyms:Gallopamil, (-)-;(S)-Gallopamil;(-)-Gallopamil;(-)-Methoxyverapamil;5X7S7C93QM;L-D-600;UNII-5X7S7C93QM;(-)-D 600;36622-40-9 (free base - rotation);36622-40-9;(S)-5-((3,4-dimethoxyphenethyl)(methyl)amino)-2-isopropyl-2-(3,4,5-trimethoxyphenyl)pentanenitrile;alpha-(3-((2-(3,4-Dimethoxyphenyl)ethyl)methylamino)propyl)-3,4,5-trimethoxy-alpha-(1-methylethyl)benzeneacetonitrile, (S)-;Benzeneacetonitrile, alpha-(3-((2-(3,4-dimethoxyphenyl)ethyl)methylamino)propyl)-3,4,5-trimethoxy-alpha-(1-methylethyl)-, (alphaS)-;methoxy verapamil;Lopac-M-5644;GALLOPAMIL, (S)-;SCHEMBL49429;CHEMBL1401296;AKOS040745806;NCGC00015686-01;NCGC00015686-02;NCGC00015686-08;Q27263000;.ALPHA.-(3-((2-(3,4-DIMETHOXYPHENYL)ETHYL)METHYLAMINO)PROPYL)-3,4,5-TRIMETHOXY-.ALPHA.-(1-METHYLETHYL)BENZENEACETONITRILE, (S)-;BENZENEACETONITRILE, .ALPHA.-(3-((2-(3,4-DIMETHOXYPHENYL)ETHYL)METHYLAMINO)PROPYL)-3,4,5-TRIMETHOXY-.ALPHA.-(1-METHYLETHYL)-, (.ALPHA.S)-

Suppliers and Price of Gallopamil, (-)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 4 raw suppliers

Chemical Property of Gallopamil, (-)-

Chemical Property:

PSA：73.18000
LogP:5.90368
Solubility.:H2O: soluble
XLogP3:3.8
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:14
Exact Mass:484.29372238
Heavy Atom Count:35
Complexity:639

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C)C(CCCN(C)CCC1=CC(=C(C=C1)OC)OC)(C#N)C2=CC(=C(C(=C2)OC)OC)OC
Isomeric SMILES:CC(C)[C@](CCCN(C)CCC1=CC(=C(C=C1)OC)OC)(C#N)C2=CC(=C(C(=C2)OC)OC)OC

Technology Process of Gallopamil, (-)-

There total 9 articles about Gallopamil, (-)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3490-06-0
N-methylhomoveratrylamine

: 116759-58-1
(S)-α-isopropyl-α-(3-methanesulfonyloxypropyl)-3,4,5-trimethoxyphenylacetonitrile

: 36622-40-9
(-)-Gallopamil

Guidance literature:: With triethylamine; In tetrahydrofuran; at 80 ℃; for 48h; Yield given;
DOI:10.1021/jo00383a026

Reference yield:

: 13230-71-2
N-[2-(3,4-dimethoxyphenyl)ethyl]-2,2,2-trifluoroacetamide

: 36622-40-9
(-)-Gallopamil

Guidance literature:: Multi-step reaction with 2 steps

1: 82 percent / NaH / tetrahydrofuran / 4 h / Ambient temperature

2: Et₃N / tetrahydrofuran / 48 h / 80 °C

With sodium hydride; triethylamine; In tetrahydrofuran;
DOI:10.1021/jo00383a026

Reference yield:

: 120-20-7
2-(3,4-dimethoxyphenyl)-ethylamine

: 36622-40-9
(-)-Gallopamil

Guidance literature:: Multi-step reaction with 3 steps

1: 99 percent / CH₂Cl₂ / 1 h / 0 °C

2: 82 percent / NaH / tetrahydrofuran / 4 h / Ambient temperature

3: Et₃N / tetrahydrofuran / 48 h / 80 °C

With sodium hydride; triethylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jo00383a026