TERT-BUTYL 4-(5-FORMYL-2-THIENYL)PIPERAZINE-1-CARBOXYLATE

Base Information

• Chemical Name: TERT-BUTYL 4-(5-FORMYL-2-THIENYL)PIPERAZINE-1-CARBOXYLATE
• CAS No.: 623588-30-7
• Molecular Formula: C14H20N2O3S
• Molecular Weight: 296.39
• Hs Code.: 2934999090
• Mol file: 623588-30-7.mol

Synonyms:TERT-BUTYL 4-(5-FORMYL-2-THIENYL)PIPERAZINE-1-CARBOXYLATE;tert-butyl 4-(5-formyl-2-thienyl)piperazine-1-carboxylate(SALTDATA: FREE);2-methyl-2-propanyl 4-(5-formyl-2-thienyl)-1-piperazinecarboxylate

Chemical Property of TERT-BUTYL 4-(5-FORMYL-2-THIENYL)PIPERAZINE-1-CARBOXYLATE

Chemical Property:

• Vapor Pressure: 2.75E-08mmHg at 25°C
• Boiling Point: 449.9°C at 760 mmHg
• Flash Point: 225.9°C
• PSA: 78.09000
• Density: 1.229g/cm³
• LogP: 2.62060

Purity/Quality:

98%min ^*data from raw suppliers

tert-Butyl 4-(5-formyl-2-thienyl)piperazine-1-carboxylate Aldrich ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of TERT-BUTYL 4-(5-FORMYL-2-THIENYL)PIPERAZINE-1-CARBOXYLATE

There total 3 articles about TERT-BUTYL 4-(5-FORMYL-2-THIENYL)PIPERAZINE-1-CARBOXYLATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

5-bromo-2-thiophencarboxaldehyde (4701-17-1) + 1-t-Butoxycarbonylpiperazine (57260-71-6) → tert-butyl 4-(5-formyl-thiophen-2-yl)piperazine-1-carboxylate (623588-30-7)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dimethyl sulfoxide; at 130 ℃; for 18h;

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) + 5-(piperazin-1-yl)thiophene-2-carboxaldehyde (851208-08-7) → tert-butyl 4-(5-formyl-thiophen-2-yl)piperazine-1-carboxylate (623588-30-7)

Guidance literature:

In ethanol; at 20 ℃; for 24h;

Reference yield:

5-bromo-2-thiophencarboxaldehyde (4701-17-1) → tert-butyl 4-(5-formyl-thiophen-2-yl)piperazine-1-carboxylate (623588-30-7)

Guidance literature:

Multi-step reaction with 2 steps

1: water / 48 h / Reflux

2: ethanol / 24 h / 20 °C

In ethanol; water;

upstream raw materials:

5-bromo-2-thiophencarboxaldehyde

1-t-Butoxycarbonylpiperazine

di-tert-butyl dicarbonate

5-(piperazin-1-yl)thiophene-2-carboxaldehyde

Downstream raw materials:

tert-butyl 4-[5-(2-{4-[tert-butoxycarbonylhydrazinocarbonylmethyl]-phenyl}vinyl)-thiophen-2-yl]piperazine-1-carboxylate