2'-C-ethynyluridine

Base Information

• Chemical Name: 2'-C-ethynyluridine
• CAS No.: 188413-98-1
• Molecular Formula: C₁₁H₁₂N₂O₆
• Molecular Weight: 268.226

Synonyms:2'-C-ethynyluridine;1-((2R,3R,4R,5R)-3-ethynyl-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione

Chemical Property of 2'-C-ethynyluridine

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

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Technology Process of 2'-C-ethynyluridine

There total 14 articles about 2'-C-ethynyluridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

2',3',5'-tri-O-benzoyl-2'-C-[(trimethylsilyl)ethynyl]uridine (188413-96-9) → 1-((2R,3R,4R,5R)-3-ethynyl-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione (188413-98-1)

Guidance literature:

With ammonia; In methanol; for 48h;

DOI:10.1021/jo961893+

Reference yield: 81.0%

(2R,3R,4R,5R)-5-((benzoyloxy)methyl)-2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3-ethynyltetrahydrofuran-3,4-diyldibenzoate (1443997-55-4) → 1-((2R,3R,4R,5R)-3-ethynyl-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione (188413-98-1)

Guidance literature:

With ammonia; In methanol; at 20 ℃; for 12h; Time;

Reference yield: 76.0%

1-((6aR,8R,9S,9aR)-9-hydroxy-2,2,4,4-tetraisopropyl-9-((trimethylsilyl)ethynyl)tetrahydro-6H-furo[3,2-f][1,3,5,2,4]trioxadisilocin-8-yl)pyrimidine-2,4(1H,3H)-dione (138481-66-0) → 1-((2R,3S,4R,5R)-3-ethynyl-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione (1051395-31-3,188413-98-1)

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; for 1h; Inert atmosphere;

DOI:10.1021/jm800261u

upstream raw materials:

2',3',5'-tri-O-benzoyl-2'-C-[(trimethylsilyl)ethynyl]uridine

(2R,3R,4R,5R)-5-((benzoyloxy)methyl)-2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3-ethynyltetrahydrofuran-3,4-diyldibenzoate

1,3,5-tri-O-benzoyl-2-oxo-α-D-erythro-pentofuranose

C₃₈H₃₄O₉Si

Downstream raw materials:

C₂₃H₂₈N₃O₉PS

C₂₃H₂₈N₃O₉PS

C₂₇H₃₄N₃O₁₁P

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