1,3-Bis(2,6-diisopropylphenyl)-2,2-difluoro-2,3-dihydro-1H-imidazole

Base Information

Chemical Name:1,3-Bis(2,6-diisopropylphenyl)-2,2-difluoro-2,3-dihydro-1H-imidazole
CAS No.:1314657-40-3
Molecular Formula:C27H36F2N2
Molecular Weight:426.593
Hs Code.:2933290090
Mol file:1314657-40-3.mol

Synonyms:1,3-Bis(2,6-diisopropylphenyl)-2,2-difluoro-2,3-dihydro-1H-imidazole;PhenoFluorTM;1,3-Bis(2,6-di-i-propylphenyl)-2,2-difluoroiMidazoline, Min. 85% (PhenoFluor;2,2-difluoro-2,3-dihydro-1,3-bis(2,6-diisopropylphenyl)-1H-iMidazole;PhenoFluor

Suppliers and Price of 1,3-Bis(2,6-diisopropylphenyl)-2,2-difluoro-2,3-dihydro-1H-imidazole

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
1,3-Bis(2,6-diisopropylphenyl)-2,2-difluoro-2,3-dihydro-1H-imidazole
25mg
$ 1390.00

Crysdot
1,3-Bis(2,6-diisopropylphenyl)-2,2-difluoro-2,3-dihydro-1H-imidazole 95+%
1g
$ 380.00

Chemenu
2,2-difluoro-2,3-dihydro-1,3-bis(2,6-diisopropylphenyl)-1H-imidazole 95%
1g
$ 450.00

Alichem
1,3-Bis(2,6-diisopropylphenyl)-2,2-difluoro-2,3-dihydro-1H-imidazole
1g
$ 400.00

Total 25 raw suppliers

Chemical Property of 1,3-Bis(2,6-diisopropylphenyl)-2,2-difluoro-2,3-dihydro-1H-imidazole

Chemical Property:

Boiling Point:445.4±45.0 °C(Predicted)
PKA:-6.13±0.40(Predicted)
Flash Point:4℃
PSA：6.48000
Density:0.865 g/mL at 25℃
LogP:8.65830
Storage Temp.:?20°C

Purity/Quality:

97% ^*data from raw suppliers

1,3-Bis(2,6-diisopropylphenyl)-2,2-difluoro-2,3-dihydro-1H-imidazole ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses PhenoFluor? reagent is utilized in deoxyfluorination of phenols, without activation of the substrate, to provide ipso substitution to the corresponding aryl fluoride.1 1,3-Bis(2,6-diisopropylphenyl)-2,2-difluoro-2,3-dihydro-1H-imidazole is used in the deoxyfluorination of heteroaromatic phenols. It also functions as a reagent used in the functional group tolerant synthesis of alkyl aryl ethers from phenols and alcohols.

Technology Process of 1,3-Bis(2,6-diisopropylphenyl)-2,2-difluoro-2,3-dihydro-1H-imidazole

There total 6 articles about 1,3-Bis(2,6-diisopropylphenyl)-2,2-difluoro-2,3-dihydro-1H-imidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 1228185-09-8
N,N′-1,3-bis(2,6-diisopropylphenyl)-2-chloroimidazolium chloride

: 1314657-40-3
1,3-bis(2,6-diisopropylphenyl)-2,2-difluoro-2,3-dihydro-1h-imidazole

Guidance literature:: With cesium fluoride; In acetonitrile; at 23 - 60 ℃; Inert atmosphere;
DOI:10.1021/ja2048072

Reference yield:

: 244187-81-3
1,3-bis-(2,6-diisopropylphenyl)-imidazol-2-ylidene

: 1311297-12-7
1,3-bis(2,6-diisopropylphenyl)-1H-imidazole-2(3H)-thione

: 1314657-40-3
1,3-bis(2,6-diisopropylphenyl)-2,2-difluoro-2,3-dihydro-1h-imidazole

Guidance literature:: With sulfur(VI) hexafluoride; In ⁽²⁾H₈-toluene; at -180 - 20 ℃; for 15h; Inert atmosphere; UV-irradiation;
DOI:10.1039/c8cc05494k

Reference yield:

: 24544-04-5
2,6-diisopropylbenzenamine

: 1314657-40-3
1,3-bis(2,6-diisopropylphenyl)-2,2-difluoro-2,3-dihydro-1h-imidazole

Guidance literature:: Multi-step reaction with 4 steps

1.1: acetic acid / methanol; water / 10.25 h / 23 - 50 °C / Inert atmosphere

2.1: chloro-trimethyl-silane / ethyl acetate / 2.75 h / 70 °C / Inert atmosphere

3.1: potassium tert-butylate / tetrahydrofuran / 4 h / 23 °C / Inert atmosphere

3.2: -40 - 23 °C / Inert atmosphere

4.1: cesium fluoride / acetonitrile / 23 - 60 °C / Inert atmosphere

With chloro-trimethyl-silane; potassium tert-butylate; acetic acid; cesium fluoride; In tetrahydrofuran; methanol; water; ethyl acetate; acetonitrile;
DOI:10.1021/ja2048072