Chemical Property of CW069
Chemical Property:
- Boiling Point:666.0±55.0 °C(Predicted)
- PKA:2.69±0.10(Predicted)
- PSA：78.43000
- Density:1.559±0.06 g/cm3(Predicted)
- LogP:4.79290
- Storage Temp.:Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
- Solubility.:≥50 mg/mL in DMSO; insoluble in H2O; ≥51.6 mg/mL in EtOH
- Purity/Quality:
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99%, *data from raw suppliers
CW069 *data from reagent suppliers
Safty Information:
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- Hazard Codes:
- MSDS Files:
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Useful:
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Description
CW069 is an allosteric inhibitor of KIFC/HSET (IC50 = 75 μM), a microtubule motor protein involved in bipolar spindle assembly and centrosome clustering. It increases the number of multipolar spindles in N1E-115 mouse neuroblastoma cells with supernumerary centrosomes when used at concentrations of 100 and 200 μM, without affecting the morphology of mitotic spindles in normal human dermal fibroblast (NHDF) cells. CW069 inhibits proliferation of N1E-115, but not NHDF, cells (IC50s = 86 and 181 μM, respectively).
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Uses
CW 069 is an allosteric inhibitor of the microtubule motor protein HSET which induces multipolar mitoses only in cells containg supernumerary centrosomes.
