CW069

Base Information

• Chemical Name: CW069
• CAS No.: 1594094-64-0
• Molecular Formula: C23H21IN2O3
• Molecular Weight: 500.33
• Mol file: 1594094-64-0.mol

Synonyms:CW069;5-Iodo-2-[[(2S)-1-oxo-3-phenyl-2-[(phenylmethyl)amino]propyl]amino]benzoic acid

Chemical Property of CW069

Chemical Property:

• Boiling Point: 666.0±55.0 °C(Predicted)
• PKA: 2.69±0.10(Predicted)
• PSA: 78.43000
• Density: 1.559±0.06 g/cm3(Predicted)
• LogP: 4.79290
• Storage Temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
• Solubility.: ≥50 mg/mL in DMSO; insoluble in H2O; ≥51.6 mg/mL in EtOH

Purity/Quality:

97% ^*data from raw suppliers

CW069 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Description: CW069 is an allosteric inhibitor of KIFC/HSET (IC50 = 75 μM), a microtubule motor protein involved in bipolar spindle assembly and centrosome clustering. It increases the number of multipolar spindles in N1E-115 mouse neuroblastoma cells with supernumerary centrosomes when used at concentrations of 100 and 200 μM, without affecting the morphology of mitotic spindles in normal human dermal fibroblast (NHDF) cells. CW069 inhibits proliferation of N1E-115, but not NHDF, cells (IC50s = 86 and 181 μM, respectively).
• Uses: CW 069 is an allosteric inhibitor of the microtubule motor protein HSET which induces multipolar mitoses only in cells containg supernumerary centrosomes.