1-(Methoxymethoxy)-4-(trifluoromethyl)benzene

Base Information

• Chemical Name: 1-(Methoxymethoxy)-4-(trifluoromethyl)benzene
• CAS No.: 174265-24-8
• Molecular Formula: C9H9F3O2
• Molecular Weight: 206.164
• DSSTox Substance ID: DTXSID80451718
• Nikkaji Number: J1.594.340H
• Wikidata: Q82271889
• Mol file: 174265-24-8.mol

Synonyms:1-(methoxymethoxy)-4-(trifluoromethyl)benzene;174265-24-8;1-Methoxymethoxy-4-(trifluoromethyl)benzene;SCHEMBL4867973;DTXSID80451718;MFCD19688630;AKOS016014797;1-methoxymethoxy-4-trifluoromethyl-benzene;4-(trifluoromethyl)phenyl methoxymethyl ether;CS-0193637;E91893;EN300-200565;J-503569

Chemical Property of 1-(Methoxymethoxy)-4-(trifluoromethyl)benzene

Chemical Property:

• PSA: 18.46000
• LogP: 2.68810
• Storage Temp.: 2-8°C
• XLogP3: 2.7
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 3
• Exact Mass: 206.05546401
• Heavy Atom Count: 14
• Complexity: 162

Purity/Quality:

≥95% ^*data from raw suppliers

1-(methoxymethoxy)-4-(trifluoromethyl)benzene ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: COCOC1=CC=C(C=C1)C(F)(F)F

Technology Process of 1-(Methoxymethoxy)-4-(trifluoromethyl)benzene

There total 1 articles about 1-(Methoxymethoxy)-4-(trifluoromethyl)benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

4-hydroxybenzotrifluoride (402-45-9) + chloromethyl methyl ether (107-30-2) → 4-(trifluoromethyl)phenyl methoxymethyl ether (174265-24-8)

Guidance literature:

4-hydroxybenzotrifluoride; With sodium; In tetrahydrofuran; Heating;

chloromethyl methyl ether; In tetrahydrofuran; for 1h;

DOI:10.1021/ja0518171

Reference yield: 98.0%

4-(trifluoromethyl)phenyl methoxymethyl ether (174265-24-8) → 2-iodo-1-(methoxymethoxy)-4-(trifluoromethyl)benzene (1449696-94-9)

Guidance literature:

4-(trifluoromethyl)phenyl methoxymethyl ether; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 0.5h;

With iodine; In tetrahydrofuran; hexane; at -78 - 20 ℃; for 22h; Inert atmosphere;

DOI:10.1021/jo400926n

Reference yield: 83.0%

oxalic acid diethyl ester (95-92-1) + 4-(trifluoromethyl)phenyl methoxymethyl ether (174265-24-8) → ethyl 2-(5-trifluoromethyl-2-(methoxymethoxy)phenyl)-2-oxoacetate

Guidance literature:

oxalic acid diethyl ester; With tert-butyl methyl ether; In tetrahydrofuran; at -78 ℃; Cooling with acetone-dry ice;

4-(trifluoromethyl)phenyl methoxymethyl ether; With n-butyllithium; In tetrahydrofuran; at -78 ℃;

DOI:10.1021/acs.orglett.5b02838

upstream raw materials:

4-hydroxybenzotrifluoride

chloromethyl methyl ether

Downstream raw materials:

2-methoxymethoxy-5-(trifluoromethyl)benzoic acid

10-hydroxy-10-(2-methoxymethoxy-5-trifluoromethylphenyl)anthrone

9-(2-methoxymethoxy-5-(trifluoromethyl)phenyl)anthracene

3-(9-anthracenyl)-2-hydroxy-5-(trifluoromethyl)benzaldehyde

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