2-acetaMido-2-deoxy-6-O-Sialyl-D-galactopyranoside (Sia--2,6-GalNAc)

Base Information

• Chemical Name: 2-acetaMido-2-deoxy-6-O-Sialyl-D-galactopyranoside (Sia--2,6-GalNAc)
• CAS No.: 948295-15-6
• Molecular Formula: C₁₉H₃₂N₂O₁₄
• Molecular Weight: 512.468
• Mol file: 948295-15-6.mol

Synonyms:2-acetaMido-2-deoxy-6-O-Sialyl-D-galactopyranoside (Sia--2,6-GalNAc)

Chemical Property of 2-acetaMido-2-deoxy-6-O-Sialyl-D-galactopyranoside (Sia--2,6-GalNAc)

Chemical Property:

• Boiling Point: 1045.5±65.0 °C (760 mmHg)
• PSA: 264.80000
• Density: 1.63±0.1 g/cm3 (20 °C, 760 mmHg)
• LogP: -5.12200

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-acetaMido-2-deoxy-6-O-Sialyl-D-galactopyranoside (Sia--2,6-GalNAc)

There total 8 articles about 2-acetaMido-2-deoxy-6-O-Sialyl-D-galactopyranoside (Sia--2,6-GalNAc) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

benzyl-2-acetamido-6-O-(5-acetamido-3,5-didesoxy-D-glycero-α-D-galacto-2-nonulopyranosylonsaeure)-3,4-di-O-benzyl-2-desoxy-β-D-galactopyranosid (97604-53-0) → 2-acetamido-6-O-(5-acetamido-3,5-didesoxy-D-glycero-α-D-galacto-2-nonulopyranosylonsaeure)-2-desoxy-D-galactopyranose (120906-42-5,948295-15-6)

Guidance literature:

With hydrogen; palladium on activated charcoal; In 1,4-dioxane; methanol; water; for 48h; Ambient temperature;

DOI:10.1016/0008-6215(85)85149-1

Reference yield: 95.0%

benzyl-2-acetamido-6-O-(5-acetamido-3,5-didesoxy-D-glycero-β-D-galacto-2-nonulopyranosylonsaeure)-3,4-di-O-benzyl-2-desoxy-β-D-galactopyranosid (97604-56-3) → 2-acetamido-6-O-(5-acetamido-3,5-didesoxy-D-glycero-β-D-galacto-2-nonulopyranosylonsaeure)-2-desoxy-D-galactopyranose (120906-42-5,948295-15-6)

Guidance literature:

With hydrogen; palladium on activated charcoal; In 1,4-dioxane; methanol; water; for 48h; Ambient temperature;

DOI:10.1016/0008-6215(85)85149-1

Reference yield: 56.2%

N-acetyl-D-galactosamine (72-87-7,1136-42-1,1136-44-3,6730-06-9,7772-94-3,10036-64-3,14131-60-3,14131-64-7,14131-68-1,14215-68-0,62057-49-2,62057-50-5,62057-51-6,62057-52-7,62057-53-8,62057-54-9,62057-55-0,62057-56-1,62075-50-7,62137-54-6,134451-97-1,134522-12-6,148347-16-4,6082-29-7) + cytidine 5'-monophosphate-N-acetylneuraminic acid (55569-66-9) → 2-acetamido-6-O-(5-acetamido-3,5-didesoxy-D-glycero-α-D-galacto-2-nonulopyranosylonsaeure)-2-desoxy-D-galactopyranose (120906-42-5,948295-15-6)

Guidance literature:

at 30 ℃; for 4h; Photobacterium damsela JT₀₁₆₀, sodium cacodilate buffer, pH 5.0;

DOI:10.1271/bbb.62.210

upstream raw materials:

benzyl-2-acetamido-6-O-(5-acetamido-3,5-didesoxy-D-glycero-β-D-galacto-2-nonulopyranosylonsaeure)-3,4-di-O-benzyl-2-desoxy-β-D-galactopyranosid

benzyl-2-acetamido-3,4-di-O-benzyl-2-desoxy-6-O--β-D-galactopyranosid

benzyl-2-acetamido-3,4-di-O-benzyl-2-desoxy-6-O--β-D-galactopyranosid

benzyl-2-acetamido-6-O-(5-acetamido-3,5-didesoxy-D-glycero-α-D-galacto-2-nonulopyranosylonsaeure)-3,4-di-O-benzyl-2-desoxy-β-D-galactopyranosid