(3S)-2-(tert-butoxycarbonyl)-2-azabicyclo[2.2.1]heptane-3-carboxylic acid

Base Information

• Chemical Name: (3S)-2-(tert-butoxycarbonyl)-2-azabicyclo[2.2.1]heptane-3-carboxylic acid
• CAS No.: 134795-25-8
• Molecular Formula: C₁₂H₁₉NO₄
• Molecular Weight: 241.287
• Mol file: 134795-25-8.mol

Synonyms:(3S)-2-(tert-butoxycarbonyl)-2-azabicyclo[2.2.1]heptane-3-carboxylic acid;2-(tert-butoxycarbonyl)-2-azabicyclo[2.2.1]heptane-2,3-dicarboxylic acid;Rel-(1S,3R,4R)-2-(tert-butoxycarbonyl)-2-azabicyclo[2.2.1]heptane-3-carboxylic acid

Chemical Property of (3S)-2-(tert-butoxycarbonyl)-2-azabicyclo[2.2.1]heptane-3-carboxylic acid

Chemical Property:

• PSA: 66.84000
• LogP: 1.79690
• Storage Temp.: 2-8°C

Purity/Quality:

2-(tert-Butoxycarbonyl)-2-azabicyclo[2.2.1]heptane-3-carboxylic acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (3S)-2-(tert-butoxycarbonyl)-2-azabicyclo[2.2.1]heptane-3-carboxylic acid

There total 51 articles about (3S)-2-(tert-butoxycarbonyl)-2-azabicyclo[2.2.1]heptane-3-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.2%

ethyl (1R,3S,4S)-2-(tert-butoxycarbonyl)-2-azabicyclo[2.2.1]heptane-3-carboxylate (188057-42-3) → (1R,3S,4S)-2-aza-bicyclo[2.2.1]heptane-2,3-dicarboxylic acid 2-tert-butyl ester (134795-25-8,291775-59-2,134877-63-7)

Guidance literature:

In tetrahydrofuran; water; at 20 ℃; for 16h;

Reference yield: 99.2%

(1R,3S,4S)-2-tert-butyl 3-ethyl 2-azabicyclo[2.2.1]heptane-2,3-dicarboxylate (161511-88-2) → (1R,3S,4S)-2-(tert-butoxycarbonyl)-2-azabicyclo[2.2.1]heptane-3-carboxylic acid (134877-62-6,134795-25-8,291775-59-2,134877-63-7)

Guidance literature:

With water; sodium hydroxide; In tetrahydrofuran; at 20 ℃; for 16h;

Reference yield: 99.0%

3-endo-2-(tert-butoxycarbonyl)-2-azabicyclo[2.2.1]hept-5-ene-3-carboxylic acid → 3-endo-2-(tert-butoxycarbonyl)-2-azabicyclo[2.2.1]heptane-3-carboxylic acid (134795-25-8,291775-59-2,134877-63-7)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethanol; at 20 ℃; for 3.5h;

upstream raw materials:

di-tert-butyl dicarbonate

(1S,3S,4R)-2-azabicyclo<2.2.1>heptane-3-carboxylic acid

(1R,3R,4S)-2-<(1S)-phenylethyl>-2-aza-bicyclo<2.2.1>hept-5-ene-3-carboxylic acid ethyl ester

ethyl (1S,3R,4R)-2-azabicyclo[2.2.1]heptane-3-carboxylate hydrochloride

Downstream raw materials:

C₅₀H₅₀N₈O₆

C₂₁H₂₈BrN₃O₄

(1R,3S,4S)-tert-butyl 3-((S)-1-cyano-2-(4-iodophenyl)ethylcarbamoyl)-2-azabicyclo[2.2.1]heptane-2-carboxylate

(1R,3S,4S)-3-[4-(4-bromo-phenyl)-1H-imidazol-2-yl]-2-aza-bicyclo[2.2.1]heptane-2-carboxylic acid tert-butyl ester