1-(2,3-Dihydro-5-hydroxy-2-Methyl-1H-indol-1-yl)-ethanone

Base Information

• Chemical Name: 1-(2,3-Dihydro-5-hydroxy-2-Methyl-1H-indol-1-yl)-ethanone
• CAS No.: 186792-92-7
• Molecular Formula: C₁₁H₁₃NO₂
• Molecular Weight: 191.23
• Mol file: 186792-92-7.mol

Synonyms:1-(2,3-Dihydro-5-hydroxy-2-Methyl-1H-indol-1-yl)-ethanone;1-Acetyl-2,3-dihydro-2-Methyl-1H-indol-5-ol

Chemical Property of 1-(2,3-Dihydro-5-hydroxy-2-Methyl-1H-indol-1-yl)-ethanone

Chemical Property:

• PSA: 40.54000
• LogP: 1.75470
• Solubility.: Dichlormethane, Dimethyl Formamide, Ethyl Acetate, Methanol

Purity/Quality:

95% ^*data from raw suppliers

1-Acetyl-2,3-dihydro-2-methyl-1H-indol-5-ol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: An indole derivative.

Technology Process of 1-(2,3-Dihydro-5-hydroxy-2-Methyl-1H-indol-1-yl)-ethanone

There total 2 articles about 1-(2,3-Dihydro-5-hydroxy-2-Methyl-1H-indol-1-yl)-ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 0.9%

1-(2-methyl-2,3-dihydro-indol-1-yl)-ethanone (131880-76-7) → N-acetyl-5-hydroxy-2-methylindoline (186792-92-7) + 1-((2R,3R)-3-Hydroxy-2-methyl-2,3-dihydro-indol-1-yl)-ethanone + 1-((2R,3S)-3-Hydroxy-2-methyl-2,3-dihydro-indol-1-yl)-ethanone

Guidance literature:

In acetone; at 28 ℃; for 72h; Cunninghamella elegans;

Reference yield:

2-methyl indoline (6872-06-6) → N-acetyl-5-hydroxy-2-methylindoline (186792-92-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 84.2 percent / glacial acetic acid / 3 h / Heating

2: 0.6 percent / acetone / 72 h / 28 °C / Cunninghamella elegans

With acetic acid; In acetone;

upstream raw materials:

1-(2-methyl-2,3-dihydro-indol-1-yl)-ethanone

2-methyl indoline