Chemical Property of 14,15-EE-5(Z)-E
Chemical Property:
- Boiling Point:452.4±18.0 °C(Predicted)
- PKA:4.76±0.10(Predicted)
- PSA：49.83000
- Density:0.957±0.06 g/cm3(Predicted)
- LogP:5.87590
- Purity/Quality:
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98% *data from raw suppliers
14,15-EE-5(Z)-E ≥98% *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:
- MSDS Files:
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SDS file from LookChem
Useful:
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Description
Epoxyeicosatrienoic acids (EETs), such as 11(12)-EET and 14(15)-EET, are cytochrome P450 metabolites of arachidonic acid that have been identified as endothelium-derived hyperpolarizing factors with vasodilator activity. 14,15-EE-5(Z)-E is a structural analog of 14,15-epoxyeicosatrienoic acids (14,15-EET) that antagonizes EET-induced relaxation of vascular smooth muscle. Relaxation of U46619-constricted bovine arteries by 14,15-EET could be inhibited approximately 80% by 14,15-EE-5(Z)-E at a concentration of 10 μM. 14,15-EE-5(Z)-E does not appear to antagonize nitric oxide- or iloprost-mediated vascular relaxation.
